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Genetic characterization, molecular epidemiology, and phylogenetic relationships of insect-specific viruses in the taxon Negevirus.
Nunes, Marcio R T; Contreras-Gutierrez, María Angélica; Guzman, Hilda; Martins, Livia C; Barbirato, Mayla Feitoza; Savit, Chelsea; Balta, Victoria; Uribe, Sandra; Vivero, Rafael; Suaza, Juan David; Oliveira, Hamilton; Nunes Neto, Joaquin P; Carvalho, Valeria L; da Silva, Sandro Patroca; Cardoso, Jedson F; de Oliveira, Rodrigo Santo; da Silva Lemos, Poliana; Wood, Thomas G; Widen, Steven G; Vasconcelos, Pedro F C; Fish, Durland; Vasilakis, Nikos; Tesh, Robert B.
Afiliação
  • Nunes MRT; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Contreras-Gutierrez MA; Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIU-Sede de Investigación Universitaria - Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias,Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Co
  • Guzman H; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Department of Arbovirology and H
  • Martins LC; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Barbirato MF; Vale S.A. - Projeto Ferro Carajás S11D, Canaã dos Carajás, Para, Brazil.
  • Savit C; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, United States.
  • Balta V; School of Public Health, University of Washington, Seattle, WA 98195, United States.
  • Uribe S; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias,Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Colombia.
  • Vivero R; Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIU-Sede de Investigación Universitaria - Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias,Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Co
  • Suaza JD; Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIU-Sede de Investigación Universitaria - Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias,Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Co
  • Oliveira H; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Nunes Neto JP; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Carvalho VL; Vale S.A. - Projeto Ferro Carajás S11D, Canaã dos Carajás, Para, Brazil.
  • da Silva SP; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Cardoso JF; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • de Oliveira RS; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • da Silva Lemos P; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Wood TG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0645, United States.
  • Widen SG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0645, United States.
  • Vasconcelos PFC; Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Fish D; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, United States.
  • Vasilakis N; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Department of Arbovirology and H
  • Tesh RB; Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States; Department of Arbovirology and H
Virology ; 504: 152-167, 2017 04.
Article em En | MEDLINE | ID: mdl-28193550
The recently described taxon Negevirus is comprised of a diverse group of insect-specific viruses isolated from mosquitoes and phlebotomine sandflies. In this study, a comprehensive genetic characterization, molecular, epidemiological and evolutionary analyses were conducted on nearly full-length sequences of 91 new negevirus isolates obtained in Brazil, Colombia, Peru, Panama, USA and Nepal. We demonstrated that these arthropod restricted viruses are clustered in two major phylogenetic groups with origins related to three plant virus genera (Cilevirus, Higrevirus and Blunevirus). Molecular analyses demonstrated that specific host correlations are not present with most negeviruses; instead, high genetic variability, wide host-range, and cross-species transmission were noted. The data presented here also revealed the existence of five novel insect-specific viruses falling into two arthropod-restrictive virus taxa, previously proposed as distinct genera, designated Nelorpivirus and Sandewavirus. Our results provide a better understanding of the molecular epidemiology, evolution, taxonomy and stability of this group of insect-restricted viruses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Genoma Viral / Aedes / Vírus de Insetos Tipo de estudo: Screening_studies Limite: Animals Idioma: En Revista: Virology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus de RNA / Genoma Viral / Aedes / Vírus de Insetos Tipo de estudo: Screening_studies Limite: Animals Idioma: En Revista: Virology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos