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Hepatitis E virus in bottlenose dolphins Tursiops truncatus.
Montalvo Villalba, María Caridad; Cruz Martínez, Danilo; Ahmad, Imran; Rodriguez Lay, Licel A; Bello Corredor, Marite; Guevara March, Celia; Martínez, Liena Sánchez; Martínez-Campo, Laima Sánchez; Jameel, Shahid.
Afiliação
  • Montalvo Villalba MC; Institute of Tropical Medicine Pedro Kouri, Autopista Novía del Mediodía, Km. 6 1/2, La Lisa, ZC 17 100, Havana, Cuba.
Dis Aquat Organ ; 123(1): 13-18, 2017 02 08.
Article em En | MEDLINE | ID: mdl-28177289
Hepatitis E virus (HEV) infects several animal species that act as zoonotic reservoirs for viral transmission. Solid and liquid residues from infected animals could lead to HEV contamination of food and surface waters. Evidence of human HEV infection through ingestion of seafood (shellfish, mussels) has been reported. Dolphins generally feed on fish and squid but are able to adapt to an environment and consume whatever prey is available. Clinical signs of infected dolphins include lethargy, inappetence, behavioral aberrations and increased serum alanine aminotransferase (ALT). The dolphins examined in this study were maintained at the National Aquarium, Havana, Cuba. A total of 31 dolphins were evaluated for HEV markers. Sera were collected and screened for total immunoglobin (Ig) anti-HEV. Sera and liver homogenate were tested for HEV RNA by nested RT-PCR using primers targeting the open reading frame 1. Phylogenetic analysis was performed using partial nucleotide sequences at the amplified RNA-dependent RNA polymerase gene. Total anti-HEV Ig was detected in 32.2% (10 of 31), and 16.1% (5 of 31) of these dolphins were positive by both serology and HEV RNA testing. Nucleotide sequence analyses revealed that HEV strains identified in dolphins were genotype 3. This virus may represent an environmental contamination of food or wastewater as a source of HEV exposure and infection. Our findings provide evidence that HEV is associated with liver disorders in cetaceans and that it is advisable to screen for exposure of this virus in captive dolphins, particularly animals with elevated serum ALT or compromised liver function test results of undetermined cause.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite E / Hepatite E / Golfinho Nariz-de-Garrafa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Dis Aquat Organ Assunto da revista: BIOLOGIA / MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite E / Hepatite E / Golfinho Nariz-de-Garrafa Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Dis Aquat Organ Assunto da revista: BIOLOGIA / MEDICINA VETERINARIA / MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha