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Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Santana-Gómez, César Emmanuel; Orozco-Suárez, Sandra Adela; Talevi, Alan; Bruno-Blanch, Luis; Magdaleno-Madrigal, Víctor Manuel; Fernández-Mas, Rodrigo; Rocha, Luisa.
Afiliação
  • Santana-Gómez CE; Department of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico.
  • Orozco-Suárez SA; Unit for Medical Research in Neurological Diseases, Specialties Hospital, National Medical Center SXXI (CMN-SXXI), Mexico City, Mexico.
  • Talevi A; Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
  • Bruno-Blanch L; Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina.
  • Magdaleno-Madrigal VM; Department of Neuroscience Research, National Institute of Psychiatry Ramon de la Fuente Muñiz, Mexico City, Mexico.
  • Fernández-Mas R; Department of Neuroscience Research, National Institute of Psychiatry Ramon de la Fuente Muñiz, Mexico City, Mexico.
  • Rocha L; Department of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico. Electronic address: lrocha@cinvestav.mx.
Neurotoxicology ; 59: 110-120, 2017 03.
Article em En | MEDLINE | ID: mdl-28174044
Propylparaben (PPB) induces cardioprotection after ischemia-reperfusion injury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2h of SE, animals receiving a single dose of PPB 1h after DZP injection presented 126% (p<0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1-13Hz bands, p<0.001), a reduced potency of 30-250Hz bands (p<0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parabenos / Estado Epiléptico / Potenciais de Ação / Ácido Glutâmico / Hipocampo / Anticonvulsivantes Limite: Animals Idioma: En Revista: Neurotoxicology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parabenos / Estado Epiléptico / Potenciais de Ação / Ácido Glutâmico / Hipocampo / Anticonvulsivantes Limite: Animals Idioma: En Revista: Neurotoxicology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Holanda