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Strategies Involving Mass Spectrometry Combined with Capillary Electrophoresis in Metabolomics.
Rodrigues, Karina Trevisan; Cieslarová, Zuzana; Tavares, Marina Franco Maggi; Simionato, Ana Valéria Colnaghi.
Afiliação
  • Rodrigues KT; Institute of Chemistry, University of São Paulo (USP), 05513-970, São Paulo, SP, Brazil.
  • Cieslarová Z; Department of Analytical Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil.
  • Tavares MF; Institute of Chemistry, University of São Paulo (USP), 05513-970, São Paulo, SP, Brazil. mfmtavar@iq.usp.br.
  • Simionato AV; Department of Analytical Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil. avsimionato@iqm.unicamp.br.
Adv Exp Med Biol ; 965: 99-141, 2017.
Article em En | MEDLINE | ID: mdl-28132178
This chapter focuses on the important contribution of CE-MS in metabolomics, describing the nature of CE-MS coupling and the technical improvements that have led to the interfaces used in modern instrumentation. Moreover, it will discourse how the variety of electrolyte compositions and additives, which has conferred CE the exceptional selectivity of its multiple separation modes, has been handled to allow interfacing with MS without compromising ionization efficiency and the spectrometer integrity. Finally, the methodologies of CE-MS in current use for metabolomics will be discussed in detail. To verify the scope of CE-MS in clinical metabolomics, a myriad of representative applications has been compiled.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Eletroforese Capilar / Metabolômica Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Eletroforese Capilar / Metabolômica Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos