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Metabolomics: Definitions and Significance in Systems Biology.
Klassen, Aline; Faccio, Andréa Tedesco; Canuto, Gisele André Baptista; da Cruz, Pedro Luis Rocha; Ribeiro, Henrique Caracho; Tavares, Marina Franco Maggi; Sussulini, Alessandra.
Afiliação
  • Klassen A; Department of Exact and Earth Sciences, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil.
  • Faccio AT; Institute of Chemistry, University of São Paulo (USP), São Paulo, SP, Brazil.
  • Canuto GA; Institute of Chemistry, University of São Paulo (USP), São Paulo, SP, Brazil.
  • da Cruz PL; Institute of Chemistry, University of São Paulo (USP), São Paulo, SP, Brazil.
  • Ribeiro HC; Laboratory of Bioanalytics and Integrated Omics (LaBIOmics), Department of Analytical Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), 6154, Campinas, SP, 13083-970, Brazil.
  • Tavares MF; Institute of Chemistry, University of São Paulo (USP), São Paulo, SP, Brazil.
  • Sussulini A; Laboratory of Bioanalytics and Integrated Omics (LaBIOmics), Department of Analytical Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), 6154, Campinas, SP, 13083-970, Brazil. sussulini@iqm.unicamp.br.
Adv Exp Med Biol ; 965: 3-17, 2017.
Article em En | MEDLINE | ID: mdl-28132174
Nowadays, there is a growing interest in deeply understanding biological mechanisms not only at the molecular level (biological components) but also the effects of an ongoing biological process in the organism as a whole (biological functionality), as established by the concept of systems biology. Within this context, metabolomics is one of the most powerful bioanalytical strategies that allow obtaining a picture of the metabolites of an organism in the course of a biological process, being considered as a phenotyping tool. Briefly, metabolomics approach consists in identifying and determining the set of metabolites (or specific metabolites) in biological samples (tissues, cells, fluids, or organisms) under normal conditions in comparison with altered states promoted by disease, drug treatment, dietary intervention, or environmental modulation. The aim of this chapter is to review the fundamentals and definitions used in the metabolomics field, as well as to emphasize its importance in systems biology and clinical studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biologia de Sistemas / Metabolômica Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biologia de Sistemas / Metabolômica Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos