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The change in serum Thiol/Disulphide homeostasis after transrectal ultrasound guided prostate biopsy.
Tokgöz, Hüsnü; Tas, Selim; Giray, Özlem; Yalçinkaya, Soner; Tokgöz, Özlem; Koca, Cemile; Savas, Murat; Erel, Özcan.
Afiliação
  • Tokgöz H; Department of Urology, Antalya Training and Research Hospital, Antalya, Turkey.
  • Tas S; Department of Urology, Antalya Training and Research Hospital, Antalya, Turkey.
  • Giray Ö; Department of Biochemistry , Antalya Training and Research Hospital, Antalya, Turkey.
  • Yalçinkaya S; Department of Urology, Antalya Training and Research Hospital, Antalya, Turkey.
  • Tokgöz Ö; Department of Radiology, Antalya Training and Research Hospital, Antalya, Turkey.
  • Koca C; Department of Biochemistry, Yildirim Beyazit University, School of Medicine, Ankara, Turkey.
  • Savas M; Department of Urology, Antalya Training and Research Hospital, Antalya, Turkey.
  • Erel Ö; Department of Biochemistry, Yildirim Beyazit University, School of Medicine, Ankara, Turkey.
Int Braz J Urol ; 43(3): 455-461, 2017.
Article em En | MEDLINE | ID: mdl-28128906
OBJECTIVES: The aim of this prospective clinical study was to investigate variations in a novel oxidative stress marker (thiol/disulphide homeostasis) in men who underwent transrectal ultrasound guided prostate biopsy (TRUSB). MATERIALS AND METHODS: A total of 22 men undergoing TRUSB of the prostate were enrolled in the study. Patients with abnormal digital rectal examination and/or total prostate specific antigen (PSA) over 4ng/mL underwent TRUSB with 12 cores. Serum samples were obtained before and just after the procedure to evaluate the possible changes in thiol/disulphide homeostasis. Mean age, total PSA and free PSA, prostate volume and histopathological data were also recorded. RESULTS: Mean age of the study population was 65.05±8.89 years. Significant decreases in native and total thiol levels were documented after the biopsy procedure. However, serum disulphide levels and disulphide/native thiol, disulphide/total thiol and native / total thiol ratios did not significantly change after TRUSB. No correlation was observed between oxidative parameters and total PSA and free PSA levels, prostate volume and histopathology of the prostate. However, mean patient age was significantly correlated with mean native and total thiol levels. CONCLUSION: Significant decreases in serum native and total thiol levels related to the prostate biopsy procedure suggest that TRUSB causes acute oxidative stress in the human body. Since our trial is the first in the current literature to investigate these oxidative stress markers in urology practice, additional studies are warranted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Compostos de Sulfidrila / Ultrassonografia / Antígeno Prostático Específico / Estresse Oxidativo / Dissulfetos Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Aged / Humans / Male Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Compostos de Sulfidrila / Ultrassonografia / Antígeno Prostático Específico / Estresse Oxidativo / Dissulfetos Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Aged / Humans / Male Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil