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Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis.
Dossi, Camila G; Cadagan, Cynthia; San Martín, Marcela; Espinosa, Alejandra; González-Mañán, Daniel; Silva, David; Mancilla, Rodrigo A; Tapia, Gladys S.
Afiliação
  • Dossi CG; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
  • Cadagan C; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
  • San Martín M; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
  • Espinosa A; Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago, Chile.
  • González-Mañán D; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
  • Silva D; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
  • Mancilla RA; School of Biochemical Engineering, Faculty of Engineering, Pontifical Catholic University of Valparaiso, Valparaiso, Chile.
  • Tapia GS; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. gtapia@med.uchile.cl.
Food Funct ; 8(2): 832-841, 2017 Feb 22.
Article em En | MEDLINE | ID: mdl-28128380
Rosa mosqueta (RM) oil is rich in α-linolenic acid (ALA) - a precursor of eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), and it has a high antioxidant activity due to its abundant content of tocopherols. Additionally, it has been observed that RM oil administration prevents hepatic steatosis. Thus, the aim of this study was to demonstrate the antilipogenic mechanism related to RM oil administration in a high-fat diet (HFD) fed mice model by evaluating markers associated with the regulation of lipid droplet metabolism (PLIN2, PLIN5 and PPAR-γ), and proteins associated with lipogenesis (FAS and SREBP-1c). C57BL/6J mice were fed either a control diet or a HFD, with and without RM oil supplementation for 12 weeks. The results showed that RM oil supplementation decreases hepatic PLIN2 and PPAR-γ mRNA expression and SREBP-1c, FAS and PLIN2 protein levels, whereas we did not find changes in the level of PLIN5 among the groups. These results suggest that modulation of lipogenic markers could be one of the mechanisms, through which RM oil supplementation prevents the hepatic steatosis induced by HFD consumption in a mice model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Rosa / Fígado Gorduroso Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Rosa / Fígado Gorduroso Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Food Funct Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido