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Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators.
Bernal-Chávez, Sergio Alberto; Pérez-Carreto, Lilia Yazmín; Nava-Arzaluz, María Guadalupe; Ganem-Rondero, Adriana.
Afiliação
  • Bernal-Chávez SA; Division de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli 54740, Estado de Mexico, Mexico. q901108@hotmail.com.
  • Pérez-Carreto LY; Division de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli 54740, Estado de Mexico, Mexico. black_greenblue@hotmail.com.
  • Nava-Arzaluz MG; Division de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli 54740, Estado de Mexico, Mexico. lupita_navaarzaluz@yahoo.com.mx.
  • Ganem-Rondero A; Division de Estudios de Posgrado (Tecnología Farmacéutica), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico, Cuautitlán Izcalli 54740, Estado de Mexico, Mexico. ganemq@hotmail.com.
Molecules ; 22(1)2017 Jan 22.
Article em En | MEDLINE | ID: mdl-28117757
The absorption modulating activity of two alkylglycerol derivatives (batyl and chimyl alcohol) on skin barrier properties was evaluated. Biophysical tests such as transepidermal water loss (TEWL) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, as well as in vitro skin permeation studies, were performed in order to determine the effect of these compounds as chemical absorption modulators. Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizic acid. The results showed that treatment of the skin with alkylglycerols caused (i) a reduction on the amount of drug permeated; (ii) a reduction in TEWL; and (iii) changes in the ATR-FTIR peaks of stratum corneum lipids, indicative of a more ordered structure. All of these findings confirm that alkyl glycerols have an absorption retarding effect on the drugs tested. Such effects are expected to give rise to important applications in the pharmaceutical and cosmetic sectors, in cases where it is desirable for the drug to remain in the superficial layers of the skin to achieve a local effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Permeabilidade / Pele / Absorção Cutânea / Portadores de Fármacos / Éteres de Glicerila Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Permeabilidade / Pele / Absorção Cutânea / Portadores de Fármacos / Éteres de Glicerila Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Suíça