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Seroprevalence of Chikungunya Virus in a Rural Community in Brazil.
Cunha, Rivaldo V; Trinta, Karen S; Montalbano, Camila A; Sucupira, Michel V F; de Lima, Maricelia M; Marques, Erenilde; Romanholi, Izilyanne H; Croda, Julio.
Afiliação
  • Cunha RV; Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • Trinta KS; Oswaldo Cruz Foundation, Campo Grande, Mato Grosso do Sul, Brazil.
  • Montalbano CA; Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Sucupira MV; Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
  • de Lima MM; Bio-Manguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Marques E; Municipal Health Department of Feira de Santana, Feira de Santana, Bahia, Brazil.
  • Romanholi IH; State University of Feira de Santana, Feira de Santana, Bahia, Brazil.
  • Croda J; State University of Feira de Santana, Feira de Santana, Bahia, Brazil.
PLoS Negl Trop Dis ; 11(1): e0005319, 2017 01.
Article em En | MEDLINE | ID: mdl-28107342
BACKGROUND: The emergence of the Chikungunya virus (CHIKV) is currently expanding. In 2015, 38,332 cases of Chikungunya were reported to the Brazilian epidemiological surveillance system. Eighteen months after notification of the first case in the city of Feira de Santana, we conducted the first serosurvey to define the magnitude of transmission in a rural community in Brazil. METHODOLOGY/MAIN FINDINGS: The serosurvey was conducted in a random sample of 450 residences in the Chapada district, located 100 kilometers from Feira de Santana. We administered questionnaires and tested 120 sera from Chapada district residents for CHIKV IgM- and IgG-specific antibodies. An individual with CHIKV infection was defined as any person with CHIKV IgM or IgG antibodies detected in the serum. One Hundred cases of Chikungunya were reported after prolonged rainfall, which reinforced the relationship between the rainfall index and CHIKV transmission. Eighteen months after the start of the outbreak, we identified a seroprevalence of 20% (95% CI, 15.4-35%). CHIKV IgG- and IgM-specific antibodies were detected in 22/120 (18.3%) and 6/120 (5.0%) individuals, respectively. Among seropositive patients, 13/24 (54.2%) reported fever and joint pain over the previous two years (p<0.01). The rate of symptomatic CHIKV infection was 40.7%. CONCLUSIONS/SIGNIFICANCE: We identified a moderate seroprevalence of Chikungunya in the Chapada district, and in half of the confirmed CHIKV infections, patients reported arthralgia and fever over the previous two years.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artralgia / Febre / Febre de Chikungunya / Anticorpos Antivirais Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artralgia / Febre / Febre de Chikungunya / Anticorpos Antivirais Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos