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ASSOCIATION STUDY BETWEEN POLYMORPHISMS OF THE p53 AND LYMPHOTOXIN ALPHA (LTA) GENES AND THE RISK OF PROLIFERATIVE VITREORETINOPATHY/RETINAL DETACHMENT IN A MEXICAN POPULATION.
Quiroz-Casian, Natalia; Lozano-Giral, David; Miranda-Duarte, Antonio; Garcia-Montalvo, Ivan; Rodriguez-Loaiza, Jose L; Zenteno, Juan C.
Afiliação
  • Quiroz-Casian N; Department of Genetics, Institute of Ophthalmology "Conde de Valenciana," Mexico City, Mexico.
  • Lozano-Giral D; Department of Genetics, Institute of Ophthalmology "Conde de Valenciana," Mexico City, Mexico.
  • Miranda-Duarte A; Department of Genetics, Instituto Nacional de Rehabilitación, Mexico City, Mexico.
  • Garcia-Montalvo I; Unit of Biochemistry ITO-UNAM, Oaxaca, Oaxaca, Mexico.
  • Rodriguez-Loaiza JL; Department of Retina, Institute of Ophthalmology "Conde de Valenciana," Mexico City, Mexico.
  • Zenteno JC; Department of Genetics, Institute of Ophthalmology "Conde de Valenciana," Mexico City, Mexico.
Retina ; 38(1): 187-191, 2018 Jan.
Article em En | MEDLINE | ID: mdl-28106707
PURPOSE: To report the results of an association study between single-nucleotide polymorphisms of the p53 and LTA genes and the risk of proliferative vitreoretinopathy (PVR)/retinal detachment (RD) in a Mexican cohort. METHODS: A total of 380 unrelated subjects were studied, including 98 patients with primary rhegmatogenous RD without PVR, 82 patients with PVR after RD surgery, and 200 healthy, ethnically matched subjects. Genotyping of single-nucleotide polymorphisms rs1042522 (p53 gene) and rs2229094 (LTA gene) was performed by direct nucleotide sequencing. Allele frequencies, genotype frequencies, and Hardy-Weinberg equilibrium were assessed with HaploView software. RESULTS: No significant differences in the allelic distributions of the previously identified risk C allele for LTA rs2229094 were observed between RD subjects and controls (odds ratio [95% confidence interval] = 0.8 [0.5-1.2]; P = 0.3). Conversely, the C allele for rs1042522 in p53 was positively associated with an increased risk for RD (odds ratio [95% confidence interval] = 1.4 [1.01-1.9]; P = 0.04). No significant differences were observed when the subgroup of 82 RD + PVR subjects was compared with the subgroup of 98 patients with RD. CONCLUSION: The C allele for rs1042522 in p53 was genetically associated with a higher risk for RD but not for PVR in this cohort. This is the first association study attempting replication of PVR-associated risk alleles in a nonwhite population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descolamento Retiniano / DNA / Proteína Supressora de Tumor p53 / Linfotoxina-alfa / Vitreorretinopatia Proliferativa / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Retina Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descolamento Retiniano / DNA / Proteína Supressora de Tumor p53 / Linfotoxina-alfa / Vitreorretinopatia Proliferativa / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Retina Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos