Your browser doesn't support javascript.
loading
DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms.
Gaspar, Neide Kalil.
Afiliação
  • Gaspar NK; Universidade Federal Fluminense (UFF) - Niterói (RJ), Brazil.
An Bras Dermatol ; 91(6): 776-780, 2016.
Article em En | MEDLINE | ID: mdl-28099600
The transforming growth factor-beta 1 (TGFß1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFß1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFß1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desidroepiandrosterona / Alopecia Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Revista: An Bras Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desidroepiandrosterona / Alopecia Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Revista: An Bras Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Espanha