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Association of prenatal and childhood PBDE exposure with timing of puberty in boys and girls.
Harley, Kim G; Rauch, Stephen A; Chevrier, Jonathan; Kogut, Katherine; Parra, Kimberly L; Trujillo, Celina; Lustig, Robert H; Greenspan, Louise C; Sjödin, Andreas; Bradman, Asa; Eskenazi, Brenda.
Afiliação
  • Harley KG; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA. Electronic address: kharley@berkeley.edu.
  • Rauch SA; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Chevrier J; Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.
  • Kogut K; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Parra KL; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Trujillo C; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Lustig RH; Department of Pediatrics, University of California, San Francisco, CA, USA.
  • Greenspan LC; Divison of Research, Kaiser Permanente, Oakland, CA, USA.
  • Sjödin A; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Bradman A; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Eskenazi B; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Environ Int ; 100: 132-138, 2017 Mar.
Article em En | MEDLINE | ID: mdl-28089583
BACKGROUND: Polybrominated diphenyl ether (PBDE) flame retardants are endocrine-disrupting chemicals that exhibit estrogenic and androgenic properties and may affect pubertal timing. METHODS: Study subjects were participants between 1999 and 2013 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal cohort study of predominantly Mexican origin families in Northern California. We measured serum concentrations of four PBDEs (BDE-47, -99, -100, -153) in blood collected from mothers during pregnancy (N=263) and their children at age 9years (N=522). We determined timing of pubertal onset in 309 boys and 314 girls using clinical Tanner staging every 9months between 9 and 13years of age, and timing of menarche by self-report. We used Poisson regression for relative risk (RR) of earlier puberty and parametric survival analysis for time ratios (TR) of pubertal milestones. RESULTS: Prenatal concentrations of all 4 congeners and Æ©PBDEs were associated with later menarche in girls (RRearlier menarche=0.5, 95% confidence interval (CI): 0.3, 0.9 for Æ©PBDEs) but earlier pubic hair development in boys (RRearlier pubarche=2.0, 95% CI: 1.3, 3.3 for Æ©PBDEs). No associations were seen between prenatal exposure and girls' breast or pubic hair development or boys' genital development. Childhood PBDE exposure was not associated with any measure of pubertal timing, except for an association of BDE-153 with later menarche. CONCLUSIONS: We found that prenatal PBDE exposure was associated with later menarche in girls but earlier pubarche in boys, suggesting opposite pubertal effects in girls and boys.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Puberdade / Exposição Ambiental / Poluentes Ambientais / Disruptores Endócrinos / Éteres Difenil Halogenados Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Int Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Puberdade / Exposição Ambiental / Poluentes Ambientais / Disruptores Endócrinos / Éteres Difenil Halogenados Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Int Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda