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Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo.
Bueno-Junior, Lezio S; Ruggiero, Rafael N; Rossignoli, Matheus T; Del Bel, Elaine A; Leite, Joao P; Uchitel, Osvaldo D.
Afiliação
  • Bueno-Junior LS; Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School University of Sao Paulo, Ribeirao Preto, Brazil.
  • Ruggiero RN; Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School University of Sao Paulo, Ribeirao Preto, Brazil.
  • Rossignoli MT; Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School University of Sao Paulo, Ribeirao Preto, Brazil.
  • Del Bel EA; Department of Morphology, Physiology and Stomatology, Dentistry School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
  • Leite JP; Department of Neuroscience and Behavioral Sciences, Ribeirao Preto Medical School University of Sao Paulo, Ribeirao Preto, Brazil jpleite@fmrp.usp.br.
  • Uchitel OD; Department of Physiology, Molecular and Cell Biology, Institute of Physiology Molecular Biology and Neuroscience University of Buenos Aires, Buenos Aires, Argentina.
Physiol Rep ; 5(1)2017 Jan.
Article em En | MEDLINE | ID: mdl-28087816
The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide - a carbonic anhydrase inhibitor - has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Anidrase Carbônica / Córtex Pré-Frontal / Acetazolamida / Neurônios Aferentes Limite: Animals Idioma: En Revista: Physiol Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Anidrase Carbônica / Córtex Pré-Frontal / Acetazolamida / Neurônios Aferentes Limite: Animals Idioma: En Revista: Physiol Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos