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Cerebellar Insulin/IGF-1 signaling in diabetic rats: Effects of exercise training.
Borges, Mariana Eiras; Ribeiro, Alessandra Mussi; Pauli, José Rodrigo; Arantes, Luciana Mendonça; Luciano, Eliete; de Moura, Leandro Pereira; de Almeida Leme, José Alexandre Curiacos; Medeiros, Alessandra; Bertolini, Natália Oliveira; Sibuya, Clarice Yoshiko; Gomes, Ricardo José.
Afiliação
  • Borges ME; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, São Paulo, Brazil.
  • Ribeiro AM; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, São Paulo, Brazil.
  • Pauli JR; Sport Science Course, University of Campinas, UNICAMP, Limeira, São Paulo, Brazil.
  • Arantes LM; Departament of Physical Education, University Center of Patos de Minas, Patos de Minas, Minas Gerais, Brazil, Brazil.
  • Luciano E; Department of Physical Education, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
  • de Moura LP; Sport Science Course, University of Campinas, UNICAMP, Limeira, São Paulo, Brazil.
  • de Almeida Leme JA; Department of Physical Education, Catholic University Center Unisalesiano, Lins, São Paulo, Brazil, Brazil.
  • Medeiros A; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, São Paulo, Brazil.
  • Bertolini NO; Department of Physical Education, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
  • Sibuya CY; Department of Physical Education, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil.
  • Gomes RJ; Department of Biosciences, São Paulo Federal University (UNIFESP), Santos, São Paulo, Brazil. Electronic address: ricardojosegomes@yahoo.com.br.
Neurosci Lett ; 639: 157-161, 2017 02 03.
Article em En | MEDLINE | ID: mdl-28034783
The Diabetes Mellitus (DM) is a chronic disease associated with loss of brain regions such as the cerebellum, increasing the risk of developing neurodegenerative diseases such as Parkinson's disease (PD). In the brain of diabetic and PD organisms the insulin/IGF-1 signaling is altered. Exercise training is an effective intervention for the prevention of neurodegerative diseases since it release neurotrophic factors and regulating insulin/IGF-1 signaling in the brain. This study aimed to evaluate the proteins involved in the insulin/IGF-1 pathway in the cerebellum of diabetic rats subjected to exercise training protocol. Wistar rats were distributed in four groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Diabetes was induced by Alloxan (ALX) (32mg/kgb.w.). The training program consisted in swimming 5days/week, 1h/day, during 6 weeks, supporting an overload corresponding to 90% of the anaerobic threshold. At the end, cerebellum was extracted to determinate the protein expression of GSK-3ß, IRß and IGF-1R and the phosphorylation of ß-amyloid, Tau, ERK1+ERK2 by Western Blot analysis. All dependent variables were analyzed by one-way analysis of variance with significance level of 5%. Diabetes causes hyperglycemia in both diabetic groups; however, in TD, there was a reduction in hyperglycemia compared to SD. Diabetes increased Tau and ß-amyloid phosphorylation in both SD and TD groups. Furthermore, aerobic exercise increased ERK1+ERK2 expression in TC. The data showed that in cerebellum of diabetic rats induced by alloxan there are some proteins expression like Parkinson cerebellum increased, and the exercise training was not able to modulate the expression of these proteins.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Transdução de Sinais / Cerebelo / Diabetes Mellitus Experimental / Hiperglicemia Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Transdução de Sinais / Cerebelo / Diabetes Mellitus Experimental / Hiperglicemia Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda