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Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy.
Silva-Freitas, Erica L; Pontes, Thales R F; Araújo-Neto, Rafael P; Damasceno, Ítalo H M; Silva, Kátia L; Carvalho, Juliana F; Medeiros, Aldo C; Silva, Rodolfo B; Silva, Amanda K A; Morales, Marco A; Egito, Eryvaldo S T; Dantas, Ana L; Carriço, Artur S.
Afiliação
  • Silva-Freitas EL; Departamento de Análises de Produtos e Ambiente, Setor de Análise de Medicamentos, Laboratório Central Dr. Almino Fernandes, Natal, RN, Brazil.
  • Pontes TRF; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Araújo-Neto RP; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Damasceno ÍHM; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Silva KL; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Carvalho JF; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Medeiros AC; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Silva RB; Departamento de Cirurgia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Silva AKA; Departamento de Física Teórica e Experimental, Universidade Federal do Rio Grande do Norte, UFRN, Avenida Senador Salgado Filho, 3000, 59078-970, Natal, RN, Brazil.
  • Morales MA; Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS, Université Paris Diderot, Paris, France.
  • Egito EST; Departamento de Física Teórica e Experimental, Universidade Federal do Rio Grande do Norte, UFRN, Avenida Senador Salgado Filho, 3000, 59078-970, Natal, RN, Brazil.
  • Dantas AL; Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
  • Carriço AS; Departamento de Física, Universidade do Estado do Rio Grande do Norte, Mossoró, RN, Brazil.
AAPS PharmSciTech ; 18(6): 2026-2036, 2017 Aug.
Article em En | MEDLINE | ID: mdl-27966176
The treatment of peptic ulcers induced by H. pylori remains challenging due to the deep mucous layer location of bacteria preventing antimicrobial drug access. The present work aimed to design and evaluate in vitro dual responsive (both pH and magnetic field-sensitive) polymeric magnetic particles loaded with amoxicillin as a smart drug carrier for deep mucous layer penetration and in situ drug release. Magnetite particles were produced by the co-precipitation method and subsequently coated with the Eudragit®S100 and amoxicillin by using the spray-drying technique. The physicochemical characterization of the obtained particles was carried out by optical and scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, nitrogen adsorption/desorption isotherms, and vibrating sample magnetometry. Additionally, drug release tests and antibacterial activity tests were evaluated in vitro. Microparticles presented 17.2 ± 0.4 µm in size and their final composition was 4.3 ± 1.5% of amoxicillin, 87.0 ± 2.3% of Eudragit, and 9.0 ± 0.3% of magnetite. They were both pH and magnetic field responsive while presenting antimicrobial activity. On one side, magnetic field responsiveness of particles is expected to prompt them to reach bacterium niche in deep mucous layer by means of magnetic forces. On the other side, pH responsiveness is expected to enable drug release in the neutral pH of the deep mucous layer, preventing undesired delivery in the acidic gastric lumen. Smart microparticles were designed presenting both pH and magnetic field responsiveness as well as antimicrobial activity. These may be promising assets for peptic ulcer treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Gastrointestinais / Portadores de Fármacos / Fenômenos Magnéticos / Amoxicilina / Anti-Infecciosos Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Gastrointestinais / Portadores de Fármacos / Fenômenos Magnéticos / Amoxicilina / Anti-Infecciosos Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos