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Household Consumption of Thiamin-Fortified Fish Sauce Increases Erythrocyte Thiamin Concentrations among Rural Cambodian Women and Their Children Younger Than 5 Years of Age: A Randomized Controlled Efficacy Trial.
Whitfield, Kyly C; Karakochuk, Crystal D; Kroeun, Hou; Sokhoing, Ly; Chan, Benny B; Borath, Mam; Sophonneary, Prak; Moore, Kirsten; Tong, Jeffery K T; McLean, Judy; Talukder, Aminuzzaman; Lynd, Larry D; Li-Chan, Eunice C Y; Kitts, David D; Green, Tim J.
Afiliação
  • Whitfield KC; Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, Nova Scotia, Canada; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Karakochuk CD; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kroeun H; Helen Keller International, Phnom Penh, Cambodia.
  • Sokhoing L; Helen Keller International, Phnom Penh, Cambodia.
  • Chan BB; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Borath M; National Sub-Committee for Food Fortification, Ministry of Planning, Phnom Penh, Cambodia.
  • Sophonneary P; National Maternal and Child Health Centre, Ministry of Health, Phnom Penh, Cambodia.
  • Moore K; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Tong JKT; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • McLean J; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Talukder A; Helen Keller International, Phnom Penh, Cambodia.
  • Lynd LD; Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
  • Li-Chan ECY; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kitts DD; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Green TJ; Food Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Discipline of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australi
J Pediatr ; 181: 242-247.e2, 2017 02.
Article em En | MEDLINE | ID: mdl-27939124
OBJECTIVES: To assess whether ad libitum consumption of thiamin-fortified fish sauce over 6 months yields higher erythrocyte thiamin diphosphate concentrations (eTDP) among women of childbearing age and their children aged 12-59 months compared with control sauce containing no thiamin. STUDY DESIGN: In this double-blind, randomized controlled efficacy trial, 276 nonpregnant, nonlactating women (18-45 years of age) and their families in Prey Veng, Cambodia, were randomized to receive 1 of 3 fish sauce formulations: low thiamin concentration (low, 2 g/L), high thiamin concentration (high, 8 g/L), or a control (no thiamin) fish sauce. Baseline (t = 0) and endline (t = 6 months) eTDP were measured with the use of high-performance liquid chromatography with a fluorescence detector. RESULTS: Fish sauce consumption did not differ between treatment groups (P = .19). In intent-to-treat analysis, women's baseline-adjusted endline eTDP (mean; 95% CI) was higher among women in the low (259; 245-274 nmol/L) and high (257; 237-276 nmol/L) groups compared with control (184; 169-198 nmol/L; P < .001); low and high groups did not differ (P = .83). Similarly, children's baseline-adjusted eTDP was higher in the low (259; 246-271 nmol/L) and high (257; 243-270 nmol/L) groups compared with control (213; 202-224 nmol/L; P < .001). CONCLUSION: Fortified fish sauce appears to be an efficacious means of improving biochemical thiamin status in nonpregnant, nonlactating women and their children (1-5 years of age) living in rural Cambodia. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02221063.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiamina / Alimentos Fortificados / Eritrócitos / Produtos Pesqueiros Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Infant / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Pediatr Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiamina / Alimentos Fortificados / Eritrócitos / Produtos Pesqueiros Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Infant / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Pediatr Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos