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Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia.
Contreras-Gutiérrez, María Angélica; Nunes, Marcio R T; Guzman, Hilda; Uribe, Sandra; Suaza Vasco, Juan David; Cardoso, Jedson F; Popov, Vsevolod L; Widen, Steven G; Wood, Thomas G; Vasilakis, Nikos; Tesh, Robert B.
Afiliação
  • Contreras-Gutiérrez MA; Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIUSde de Investigación Universitaria - Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Colombia.
  • Nunes MRT; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Guzman H; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Uribe S; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Colombia.
  • Suaza Vasco JD; Programa de Estudio y Control de Enfermedades Tropicales - PECET - SIUSde de Investigación Universitaria - Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Sistemática Molecular-GSM, Facultad de Ciencias, Universidad Nacional de Colombia, sede Medellín, Medellín, Colombia.
  • Cardoso JF; Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, Para, Brazil.
  • Popov VL; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
  • Widen SG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Wood TG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
  • Vasilakis N; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: nivasila@utmb.edu.
  • Tesh RB; Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: rtesh@utmb.edu.
Virology ; 501: 166-175, 2017 01 15.
Article em En | MEDLINE | ID: mdl-27936462
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Evolução Molecular / Culicidae Limite: Animals País/Região como assunto: America do sul / Colombia Idioma: En Revista: Virology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Evolução Molecular / Culicidae Limite: Animals País/Região como assunto: America do sul / Colombia Idioma: En Revista: Virology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos