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Relationship between the Finnish Diabetes Risk Score (FINDRISC), vitamin D levels, and insulin resistance in obese subjects.
Lima-Martínez, Marcos M; Arrau, Carlos; Jerez, Saimar; Paoli, Mariela; González-Rivas, Juan P; Nieto-Martínez, Ramfis; Iacobellis, Gianluca.
Afiliação
  • Lima-Martínez MM; Endocrinology, Diabetes, Metabolism and Nutrition Unit, Ciudad Bolívar, Venezuela; Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela. Electronic address: marcoslimamedical@hotmail.com.
  • Arrau C; Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela.
  • Jerez S; Physiological Sciences Department, Universidad de Oriente, Ciudad Bolívar, Venezuela.
  • Paoli M; Autonomous Institute the Andes University Hospital, Endocrinology Unit, Mérida, Venezuela.
  • González-Rivas JP; The Andes Clinic of Cardio-Metabolic Studies, Mérida, Venezuela.
  • Nieto-Martínez R; Department of Physiology, School of Medicine, Universidad Centro-Occidental "Lisandro Alvarado" and Cardio-metabolic Unit 7, Barquisimeto, Venezuela; Department of Physiology, School of Medicine, University of Panamá, Panama City, Panama.
  • Iacobellis G; Division of Endocrinology, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA.
Prim Care Diabetes ; 11(1): 94-100, 2017 02.
Article em En | MEDLINE | ID: mdl-27914905
AIM: To assess the relationship between 25-hydroxyvitamin D [25(OH)D] blood concentrations in subjects with obesity and type 2 diabetes mellitus (T2D) risk according to the Finnish Diabetes Risk Score (FINDRISC) modified for Latin America (LA-FINDRISC). METHODS: This study was conducted in Ciudad Bolívar, Venezuela. Eighty two women and 20 men (53 obese and 49 nonobese), with an average age of 42.6±12.30 years were enrolled. Weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, basal insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and 25(OH)D levels were measured. FINDRISC with WC cutoff points modified for Latin America was applied. RESULTS: No difference in 25(OH)D levels between obese and nonobese subjects was found. When anthropometric, clinical, and biochemical variables according to the 25(OH)D status were compared, the only difference detected was higher LA-FINDRISC in the insufficient/low 25(OH)D group compared to normal 25(OH)D levels group (12.75±6.62; vs 10.15±5.21; p=0.031). LA-FINDRISC was negatively correlated with plasma 25(OH)D levels (r=-0.302; p=0.002) and positively correlated with the HOMA-IR index (r=0.637; p=0.0001). CONCLUSIONS: The LA-FINDRISC significantly correlated with both 25(OH)D levels and insulin resistance markers in this group of patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Resistência à Insulina / Inquéritos e Questionários / Diabetes Mellitus Tipo 2 / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Prim Care Diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Resistência à Insulina / Inquéritos e Questionários / Diabetes Mellitus Tipo 2 / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Prim Care Diabetes Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido