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Escherichia coli clonal group A among uropathogenic infections in Mexico City.
Manjarrez-Hernandez, Angel; Molina-López, José; Gavilanes-Parra, Sandra; Hernandez-Castro, Rigoberto.
Afiliação
  • Manjarrez-Hernandez A; Dirección de Investigación, Hospital General Dr. Gea González, Tlalpan, Ciudad de México 14080, Mexico.
  • Molina-López J; Departamento de Salud Pública, Facultad de Medicina, UNAM, Ciudad de México 04510, Mexico.
  • Gavilanes-Parra S; Departamento de Salud Pública, Facultad de Medicina, UNAM, Ciudad de México 04510, Mexico.
  • Hernandez-Castro R; Laboratorio de Patogenicidad Bacteriana, Edificio de Investigación Hemato-Oncología 5to, Piso Hospital Infantil de México 'Federico Gómez', C.P. 06720 Ciudad de México, Mexico.
J Med Microbiol ; 65(12): 1438-1444, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27902433
Escherichia coli clonal group A (CGA) causes urinary tract and other extra-intestinal infections in humans. CGA is an important cause of trimethoprim/sulfamethoxazole (SXT) resistance in extra-intestinal pathogens. We examined the extent to which resistance in this area is related to CGA dissemination of E. coli from urinary tract infections (UTIs) in Mexico City. The virulence backgrounds of the isolates were also characterized. In this study, the frequency of resistance to SXT used for UTI treatment was high (56-65 %), and CGA isolates accounted for 9 of the 78 SXT-resistant isolates (11.5 %). Although all CGA isolates were found to be multidrug resistant (MDR), none of them were extended-spectrum ß-lactamase-producing organisms. The prevalence of CGA among the 45 MDR isolates that we identified was 20 %, indicating that this clonal group moderately contributes to the antibiotic resistance of uropathogenic E. coli isolates in this region. Most of the nine CGA isolates carried transferable, large-size plasmids of approximately 80 to 100 kb, which were able to transfer antimicrobial resistance to E. coli J53 in mating assays. CGA isolates mainly belonged to phylogenetic groups F and D. We found no association between antimicrobial resistance and virulence-associated genes: the median virulence scores of CGA isolates were slightly higher (4.6) than those of non-CGA isolates, whether they were susceptible (3.7) or resistant (3.5) to SXT. Our results indicate that CGA is not a major contributor to the high level of resistance to SXT in this region but, instead, seems to be an important constituent of MDR isolates from UTIs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Infecções por Escherichia coli / Escherichia coli Uropatogênica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: J Med Microbiol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Infecções por Escherichia coli / Escherichia coli Uropatogênica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Mexico Idioma: En Revista: J Med Microbiol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido