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Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?
Sahin, Murat; Demircioglu, Didem; Oguz, Ayten; Tuzun, Dilek; Sarica, Mehmet Akif; Inanc, Elif; Gul, Kamile.
Afiliação
  • Sahin M; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
  • Demircioglu D; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Internal Medicine, Kahramanmaras, Turkey.
  • Oguz A; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
  • Tuzun D; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
  • Sarica MA; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Radiodiagnostic, Kahramanmaras, Turkey.
  • Inanc E; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Internal Medicine, Kahramanmaras, Turkey.
  • Gul K; Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kahramanmaras, Turkey.
Arch Endocrinol Metab ; 61(2): 145-151, 2017.
Article em En | MEDLINE | ID: mdl-27901182
OBJECTIVE: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). SUBJECTS AND METHODS: 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants. Thyroid and pelvic ultrasound were performed in all participants. RESULTS: Insulin, HOMA-IR, LH, E2 and TV were higher in PCOS group (p < 0.05). TV was significantly higher in PCOS patients with IR compared to non-IR PCOS patients (p < 0.001), while TSH, fT4, and urine iodine levels were similar between these groups (p > 0.05). There was a negative correlation between E2 and TSH (p < 0.05) and a positive correlation between TSH and TV (p < 0.05). There was a significant positive correlation between TV and LH, insulin, HOMA-IR (p < 0.05). CONCLUSION: This study showed that TV was increased in patients with insulin resistance but differences in TSH and LH levels may affect TV changes as well.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Glândula Tireoide / Resistência à Insulina / Gonadotropinas Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Glândula Tireoide / Resistência à Insulina / Gonadotropinas Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Arch Endocrinol Metab Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil