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Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia.
Mori, Marco Aurélio; Meyer, Erika; Soares, Ligia Mendes; Milani, Humberto; Guimarães, Francisco Silveira; de Oliveira, Rúbia Maria Weffort.
Afiliação
  • Mori MA; Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil.
  • Meyer E; Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil.
  • Soares LM; Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil.
  • Milani H; Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil.
  • Guimarães FS; Department of Pharmacology, School of Medicine, USP, Av. Bandeirantes, 14015-000 Ribeirão Preto, São Paulo, Brazil.
  • de Oliveira RMW; Department of Pharmacology and Therapeutics, State University of Maringá, Av. Colombo, 5790, 87020-900 Maringá, Paraná, Brazil. Electronic address: rmmwoliveira@uem.br.
Prog Neuropsychopharmacol Biol Psychiatry ; 75: 94-105, 2017 04 03.
Article em En | MEDLINE | ID: mdl-27889412
This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and emotional impairments induced by bilateral common carotid artery occlusion (BCCAO) in mice. Using a multi-tiered behavioral testing battery during 21days, we found that BCCAO mice exhibited long-lasting functional deficits reflected by increase in anxiety-like behavior (day 9), memory impairments (days 12-18) and despair-like behavior (day 21). Short-term CBD 10mg/kg treatment prevented the cognitive and emotional impairments, attenuated hippocampal neurodegeneration and white matter (WM) injury, and reduced glial response that were induced by BCCAO. In addition, ischemic mice treated with CBD exhibited an increase in the hippocampal brain derived neurotrophic factor (BDNF) protein levels. CBD also stimulated neurogenesis and promoted dendritic restructuring in the hippocampus of BCCAO animals. Collectively, the present results demonstrate that short-term CBD treatment results in global functional recovery in ischemic mice and impacts multiple and distinct targets involved in the pathophysiology of brain ischemic injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol / Isquemia Encefálica / Recuperação de Função Fisiológica / Encefalite / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canabidiol / Isquemia Encefálica / Recuperação de Função Fisiológica / Encefalite / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido