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Efficacy and safety of amphotericin B lipid-based formulations-A systematic review and meta-analysis.
Steimbach, Laiza M; Tonin, Fernanda S; Virtuoso, Suzane; Borba, Helena H L; Sanches, Andréia C C; Wiens, Astrid; Fernandez-Llimós, Fernando; Pontarolo, Roberto.
Afiliação
  • Steimbach LM; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Research Program, Federal University of Paraná, Curitiba, Brazil.
  • Tonin FS; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Research Program, Federal University of Paraná, Curitiba, Brazil.
  • Virtuoso S; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Research Program, Federal University of Paraná, Curitiba, Brazil.
  • Borba HH; Department of Medical and Pharmaceutical Sciences, West-Stadual University of Parana (UNIOESTE), Cascavel, Brazil.
  • Sanches AC; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Research Program, Federal University of Paraná, Curitiba, Brazil.
  • Wiens A; Department of Medical and Pharmaceutical Sciences, West-Stadual University of Parana (UNIOESTE), Cascavel, Brazil.
  • Fernandez-Llimós F; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Research Program, Federal University of Paraná, Curitiba, Brazil.
  • Pontarolo R; Department of Social Pharmacy, Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, University of Lisboa, Lisbon, Portugal.
Mycoses ; 60(3): 146-154, 2017 Mar.
Article em En | MEDLINE | ID: mdl-27878878
Invasive fungal infections, an important cause of mortality, are primarily treated using amphotericin B, which is available in different formulations, both conventional and lipid-based (liposomal, lipid complex, colloidal dispersion and Intralipid® infusion). The aim of our study was to determine the efficacy and safety of conventional amphotericin B vs its lipid-based formulations. A systematic review followed by pairwise meta-analysis was performed, including randomised controlled trials (RCTs) that evaluated the use of lipid-based amphotericin B in patients with any degree of immunosuppression and susceptibility to invasive fungal infection. An electronic search was conducted using PubMed, Scopus, Web of Science and Scielo databases. Extracted outcomes were related to efficacy (cure) and safety (incidence of adverse events). Results were evaluated and meta-analyses were performed. Twenty-three RCTs were identified (n=2677 participants) for meta-analysis. No significant differences between conventional amphotericin B and any of the five formulations evaluated were observed, with regard to the efficacy analysis. With respect to the adverse events of nephrotoxicity, fever, chills and vomiting, all lipid formulations presented better profiles than the conventional formulation. The present systematic review and meta-analysis showed that conventional amphotericin B presents the same efficacy profile as lipid-based formulations, although the latter were associated with a safer profile.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anfotericina B / Infecções Fúngicas Invasivas / Antifúngicos Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Revista: Mycoses Assunto da revista: MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anfotericina B / Infecções Fúngicas Invasivas / Antifúngicos Tipo de estudo: Clinical_trials / Systematic_reviews Limite: Humans Idioma: En Revista: Mycoses Assunto da revista: MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha