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Strength and Aerobic Exercises Improve Spatial Memory in Aging Rats Through Stimulating Distinct Neuroplasticity Mechanisms.
Vilela, Thais Ceresér; Muller, Alexandre Pastoris; Damiani, Adriani Paganini; Macan, Tamires Pavei; da Silva, Sabrina; Canteiro, Paula Bortoluzzi; de Sena Casagrande, Alisson; Pedroso, Giulia Dos Santos; Nesi, Renata Tiscoski; de Andrade, Vanessa Moraes; de Pinho, Ricardo Aurino.
Afiliação
  • Vilela TC; Laboratory of Molecular and Cellular Biology Graduate Programme of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • Muller AP; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil. alexandrep.muller@gmail.com.
  • Damiani AP; Laboratory of Molecular and Cellular Biology Graduate Programme of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • Macan TP; Laboratory of Molecular and Cellular Biology Graduate Programme of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • da Silva S; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • Canteiro PB; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • de Sena Casagrande A; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • Pedroso GDS; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • Nesi RT; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
  • de Andrade VM; Laboratory of Molecular and Cellular Biology Graduate Programme of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil. vma@unesc.net.
  • de Pinho RA; Laboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense-UNESC, 1105, Universitária Rd, Criciúma, SC, 88806000, Brazil.
Mol Neurobiol ; 54(10): 7928-7937, 2017 12.
Article em En | MEDLINE | ID: mdl-27878552
Aging is associated with impaired cognition and memory and increased susceptibility to neurodegenerative disorders. Physical exercise is neuroprotective; however, the major evidence of this effect involves studies of only aerobic training in young animals. The benefits of other exercise protocols such as strength training in aged animals remains unknown. Here, we investigated the effect of aerobic and strength training on spatial memory and hippocampal plasticity in aging rats. Aging Wistar rats performed aerobic or strength training for 50 min 3 to 4 days/week for 8 weeks. Spatial memory and neurotrophic and glutamatergic signaling in the hippocampus of aged rats were evaluated after aerobic or strength training. Both aerobic and strength training improved cognition during the performance of a spatial memory task. Remarkably, the improvement in spatial memory was accompanied by an increase in synaptic plasticity proteins within the hippocampus after exercise training, with some differences in the intracellular functions of those proteins between the two exercise protocols. Moreover, neurotrophic signaling (CREB, BDNF, and the P75NTR receptor) increased after training for both exercise protocols, and aerobic exercise specifically increased glutamatergic proteins (NMDA receptor and PSD-95). We also observed a decrease in DNA damage after aerobic training. In contrast, strength training increased levels of PKCα and the proinflammatory factors TNF-α and IL-1ß. Overall, our results show that both aerobic and strength training improved spatial memory in aging rats through inducing distinct molecular mechanisms of neuroplasticity. Our findings extend the idea that exercise protocols can be used to improve cognition during aging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Envelhecimento / Cognição / Memória Espacial / Plasticidade Neuronal Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Envelhecimento / Cognição / Memória Espacial / Plasticidade Neuronal Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos