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Characterization and immunomodulatory effects of glucans from Pleurotus albidus, a promising species of mushroom for farming and biomass production.
Castro-Alves, Victor Costa; Gomes, Daniel; Menolli, Nelson; Sforça, Maurício Luís; Nascimento, João Roberto Oliveira do.
Afiliação
  • Castro-Alves VC; Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Gomes D; Sao Paulo Agency for Agribusiness Technology (APTA), Monte Alegre do Sul, SP, Brazil.
  • Menolli N; Department of Science and Mathematics, Subarea of Biology, Federal Institute of Education, Science and Technology of São Paulo (IFSP), São Paulo, SP, Brazil; Nucleus of Research in Mycology, Botanical Institute, São Paulo, SP, Brazil.
  • Sforça ML; Laboratory of Nuclear Magnetic Resonance, Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil.
  • Nascimento JR; Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo, SP, Brazil; Food Research Center (FoRC), CEPID-FAPESP (Research, Innovation and Di
Int J Biol Macromol ; 95: 215-223, 2017 Feb.
Article em En | MEDLINE | ID: mdl-27876596
Polysaccharides from a number of mushroom species are recognized as functional food ingredients with potential health benefits, including immunomodulatory effects. In this study, polysaccharides extracted from the basidiome with cold water (BaCW), hot water (BaHW), and hot alkali (BaHA) solution, and exo- (MyEX) and endopolysaccharides (MyEN) from the submerged culture of Pleurotus albidus, a promising species for farming and biomass production, were analyzed for their chemical composition and structure and immunomodulatory effects on macrophages. Compositional (HPAEC-PAD and HPSEC-RID/MWD) and structural (FT-IR, 1D- and 2D-NMR) analyses identified BaCW and MyEX as ß-(1,6)-branched ß-(1,3)-glucans, BaHW and MyEN as α-(1,3)-(1,2)-branched α-(1,6)-glucans, and BaHA as a mixture of α-(1,6)- and ß-(1,3)-glucans. BaCW and MyEX stimulated the production of tumor necrosis factor alpha (TNF-α) and nitric oxide (NO), but not interleukin-6 (IL-6), and decreased phagocytosis of zymosan particles. In contrast, BaHW and MyEN induced TNF-α, NO and IL-6 production, and increased zymosan phagocytosis, while BaHA displayed intermediary effects in comparison the other polysaccharides. In conclusion, the basidiome and the submerged culture of P. albidus are sources of easily extractable α- and ß-glucans with potential immunomodulatory effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomassa / Pleurotus / Agricultura / Glucanos / Fatores Imunológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomassa / Pleurotus / Agricultura / Glucanos / Fatores Imunológicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda