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Diabetes mellitus in childhood: an emerging condition in the 21st century.
Della Manna, Thais; Setian, Nuvarte; Savoldelli, Roberta Diaz; Guedes, Dulce Rondina; Kuperman, Hilton; Menezes, Hamilton Cabral; Steinmetz, Leandra; Cominato, Louise; Dichtchekenian, Vaê; Damiani, Durval.
Afiliação
  • Della Manna T; PhD in Sciences from Faculdade de Medicina, Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
  • Setian N; Associate Professor, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Savoldelli RD; PhD Student, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Guedes DR; PhD in Sciences from FMUSP, São Paulo, SP, Brazil.
  • Kuperman H; PhD in Sciences from FMUSP, São Paulo, SP, Brazil.
  • Menezes HC; MSc in Medicine from FMUSP, São Paulo, SP, Brazil.
  • Steinmetz L; MSc from FMUSP, São Paulo, SP, Brazil.
  • Cominato L; MSc from FMUSP, São Paulo, SP, Brazil.
  • Dichtchekenian V; PhD in Pediatrics from FMUSP, São Paulo, SP, Brazil.
  • Damiani D; Professor, Habilitation (BR: Livre-docência), Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992) ; 62(6): 594-601, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27849238
The International Diabetes Federation (IDF-2015) estimates the existence of 30,900 children under 15 years old with type 1 diabetes mellitus (DM1) in Brazil, and an increase of 3.0% per year is expected. This review focused on meta-analysis and pediatric diabetes update articles in order to draw attention to the need of planning coping strategies to support this serious public health problem in coming years. DM1 is considered an immuno-mediated disease with a complex transmission influenced by genetic and environmental factors responsible for a gradual destruction of the insulin producing pancreatic beta cells. Seroconversion to DM1-associated autoantibodies and abnormalities in metabolic tests that assess insulin secretion and glucose tolerance can be used as predictive criteria of beta cells functional reserve and the onset of the clinical disease. Symptomatic DM1 treatment is complex and the maintenance of good metabolic control is still the only effective strategy for preserving beta cell function. Disease duration and hyperglycemia are both risk factors for the onset of chronic vascular complications that negatively affect the quality of life and survival of these patients. In this regard, health teams must be trained to provide the best possible information on pediatric diabetes, through continuing education programs focused on enabling these young people and their families to diabetes self-management.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Child, preschool / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Child, preschool / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil