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Cow's milk allergy: Evaluating tolerance through skin-prick test.
Neves, Flavia Valença de Oliveira; Beck, Cleonir de Moraes Lui; Gushken, Andrea Keiko Fujinami; Yonamine, Glauce Hiromi; Castro, Ana Paula Beltran Moschione; Dorna, Mayra de Barros; Santos, Cristiane de Jesus Nunes Dos; Pastorino, Antonio Carlos.
Afiliação
  • Neves FV; MSc from Faculdade de Medicina, Universidade de São Paulo (FMUSP). Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Beck CM; MSc from Faculdade de Medicina, Universidade de São Paulo (FMUSP). Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Gushken AK; MSc from Faculdade de Medicina, Universidade de São Paulo (FMUSP). Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Yonamine GH; MSc from FMUSP. Division of Nutrition, Hospital das Clínicas, FMUSP, São Paulo, SP, Brazil.
  • Castro AP; MSc and PhD in Sciences from FMUSP. Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Dorna MB; MSc from Faculdade de Medicina, Universidade de São Paulo (FMUSP). Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Santos CJ; Assistant, Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
  • Pastorino AC; MSc and PhD in Sciences from FMUSP. Head of the Unit of Allergy and Immunology, Department of Pediatrics, FMUSP, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992) ; 62(6): 537-543, 2016 Sep.
Article em En | MEDLINE | ID: mdl-27849231
OBJECTIVE:: To evaluate the wheal diameter in allergy skin-prick tests (SPT) with cow's milk extract (CM) comparing tolerant and persistent patients. METHOD:: A retrospective cohort study involving database analysis of children with diagnosis of cow's milk protein allergy (CMPA) mediated by immunoglobulin E in a specialized outpatient clinic that regularly performed SPT between January 2000 and July 2015. Patients were allocated into two groups: tolerant or persistent. Comparisons were made at diagnosis and over time between tolerant and persistent patients using Fisher's, Mann-Whitney or Wilcoxon tests and significance level at 5%. RESULTS:: After applying inclusion and exclusion criteria, the sample includes 44 patients (29 tolerant and 15 who persisted with CMPA). In the tolerant group, the medians of SPT were: 6 mm at diagnosis and 2 mm at the development of tolerance; a significant difference (p<0.0001) was found. In the persistent group, the median SPT at diagnosis was 7 mm, while in the last SPT it was 5 mm, with no statistical difference (p=0.173). The comparison of medians in the last SPT between groups was significant (p=0.001), with a reduction greater than 50% in SPT in the tolerant group. CONCLUSION:: Serial SPTs were useful for diagnosis, and a decrease higher than 50% in diameter can indicate the moment to perform oral food challenge (OFC) tests, helping to detect tolerance in CMPA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Testes Cutâneos / Hipersensibilidade a Leite Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina E / Testes Cutâneos / Hipersensibilidade a Leite Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Rev Assoc Med Bras (1992) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil