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Circadian preferences, oxidative stress and inflammatory cytokines in bipolar disorder: A community study.
Mondin, Thaise Campos; de Azevedo Cardoso, Taiane; Moreira, Fernanda Pedrotti; Wiener, Carolina; Oses, Jean Pierre; de Mattos Souza, Luciano Dias; Jansen, Karen; da Silva Magalhães, Pedro Vieira; Kapczinski, Flávio; da Silva, Ricardo Azevedo.
Afiliação
  • Mondin TC; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
  • de Azevedo Cardoso T; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil.
  • Moreira FP; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
  • Wiener C; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
  • Oses JP; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 19
  • de Mattos Souza LD; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil.
  • Jansen K; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil.
  • da Silva Magalhães PV; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States.
  • Kapczinski F; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States.
  • da Silva RA; Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil. Electronic address: ricardo.as@uol.com.br.
J Neuroimmunol ; 301: 23-29, 2016 12 15.
Article em En | MEDLINE | ID: mdl-27836181
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. A sample of 215 participants, in whom we measured circadian preferences, IL-6, IL-10, TNF-α, TBARS, uric acid, PCC. Biological rhythms were evaluated using the Biological Interview of Assessment in Neuropsychiatry. RESULTS: Bipolar group presented a higher alteration in biological rhythms (40.40±9.78) when compared with the major depression group (36.35±9.18) and control group (27.61±6.89) p<0.001. Subjects with bipolar disorder who were active at night and had a day/night cycle reverse showed decreased levels of IL-6 (t, 44=2.096; p=0.042), (t, 44=2.213; p=0.032), respectively. In the bipolar disorder group subjects who presented day/night cycle reverse had lower TBARS levels (t, 41=2.612; p=0.013). TNF-α were decreased in subjects more active at night with bipolar disorder. CONCLUSION: Lower serum levels of IL-6, TNF-α and TBARS were associated with evening preference in bipolar disorder group. These findings suggest that chronotype may alter the levels of interleukins and oxidative stress levels in bipolar and healthy subjects. A better understanding of the role of circadian preferences in levels of interleukins and oxidative stress are needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Citocinas / Ritmo Circadiano / Estresse Oxidativo Tipo de estudo: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Neuroimmunol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Citocinas / Ritmo Circadiano / Estresse Oxidativo Tipo de estudo: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Neuroimmunol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda