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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.
Izmirli, Muzeyyen; Sen, Bilge Bulbul; Rifaioglu, Eminenur; Gogebakan, Bulent; Aldemir, Ozgur; Sen, Tuba; Ekiz, Ozlem; Alptekin, Davut.
Afiliação
  • Izmirli M; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Sen BB; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Rifaioglu E; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Gogebakan B; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Aldemir O; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Sen T; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Ekiz O; Mustafa Kemal University, Medical School - Hatay, Turkey.
  • Alptekin D; Cukurova University, Medical School - Adana, Turkey.
An Bras Dermatol ; 91(5): 611-613, 2016.
Article em En | MEDLINE | ID: mdl-27828634
BACKGROUND:: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). OBJECTIVE:: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. METHODS:: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. RESULTS:: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). CONCLUSION:: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Psoríase / Metilenotetra-Hidrofolato Redutase (NADPH2) Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: An Bras Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Turquia País de publicação: Espanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Psoríase / Metilenotetra-Hidrofolato Redutase (NADPH2) Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: An Bras Dermatol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Turquia País de publicação: Espanha