Your browser doesn't support javascript.
loading
Association between a non-synonymous HSD17B4 single nucleotide polymorphism and meat-quality traits in Berkshire pigs.
Jo, J L; Hwang, J H; Kwon, S G; Park, D H; Kim, T W; Kang, D G; Yu, G E; Kim, I S; Ha, J G; Kim, C W.
Afiliação
  • Jo JL; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Hwang JH; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Kwon SG; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Park DH; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Kim TW; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Kang DG; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Yu GE; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Kim IS; Department of Animal Resource Technology, Gyeongnam National University of Science & Technology, Jinju, South Korea.
  • Ha JG; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea jiha@gntech.ac.kr.
  • Kim CW; Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea jiha@gntech.ac.kr.
Genet Mol Res ; 15(4)2016 Nov 03.
Article em En | MEDLINE | ID: mdl-27819726
Single nucleotide polymorphisms (SNPs) are useful genetic markers that allow correlation of genetic sequences with phenotypic traits. It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during ß-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:128,825,976A>G, c.2137A>G, I690V, within the sterol carrier protein-2 domain of the HSD17B4 gene, by RNA-Seq of liver RNA. The HSD17B4 mRNA was highly expressed in the kidney and liver among various other tissues in four pig breeds, namely, Berkshire, Duroc, Landrace, and Yorkshire. The nsSNP was significantly associated with carcass weight, backfat thickness, and drip loss (P < 0.05). Furthermore, HSD17B4 may play a crucial role during the early stages of myogenesis when expression of its mRNA was significantly high. In conclusion, HSD17B4 may serve as a possible regulator of muscle development, and its identification should help to select for improved economic traits of Berkshire pigs such as carcass weight, backfat thickness, and drip loss.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Característica Quantitativa Herdável / Polimorfismo de Nucleotídeo Único / Sus scrofa / Estudos de Associação Genética / 17-Hidroxiesteroide Desidrogenases / Carne Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Característica Quantitativa Herdável / Polimorfismo de Nucleotídeo Único / Sus scrofa / Estudos de Associação Genética / 17-Hidroxiesteroide Desidrogenases / Carne Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Brasil