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Diazepam influences urinary bioindicator of occupational toluene exposure.
Silveira, Alberto Thalison; Albuquerque, Ana Carolina Campos; Lepera, José Salvador; Martins, Isarita.
Afiliação
  • Silveira AT; Laboratory of Toxicant and Drug Analyses, Federal University of Alfenas, Unifal-MG, Alfenas, MG, Brazil.
  • Albuquerque ACC; Laboratory of Toxicant and Drug Analyses, Federal University of Alfenas, Unifal-MG, Alfenas, MG, Brazil.
  • Lepera JS; Laboratory of Occupational Toxicology, Faculty of Pharmaceutical Sciences of Araraquara - FCFAr, UNESP, Araraquara, SP, Brazil.
  • Martins I; Laboratory of Toxicant and Drug Analyses, Federal University of Alfenas, Unifal-MG, Alfenas, MG, Brazil. Electronic address: isarita.sakakibara@unifal-mg.edu.br.
Environ Toxicol Pharmacol ; 48: 191-196, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27816004
In the present study, we investigated the influence of diazepam (DZP) on the excretion of TOL by examining their urinary metabolites, hippuric acid (HA) and ortho-cresol (o-C). Male Wistar rats were exposed to TOL (20ppm) in a nose-only exposure chamber (6h/day, 5days/week for 6 weeks) with simultaneous administration of DZP (10mg/kg/day). Urinary o-C levels were determined by GC-MS, while HA, creatinine (CR), DZP and its metabolite, nordiazepam, were analysed by HPLC-DAD. The results of a Mann-Whitney U test showed that DZP influenced the urinary excretion of o-C (p<0.05). This pioneering study revealed that there was an interaction between DZP and TOL, probably by the inhibition of the CYP isoforms (CYP2B6, CYP2C8, CYP2E1, and CYP1A2) involved in the oxidative metabolism of the solvent. This is relevant information to be considered in the biomonitoring of occupational toluene exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolueno / Exposição Ocupacional / Exposição por Inalação / Cresóis / Poluentes Ocupacionais do Ar / Diazepam Limite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolueno / Exposição Ocupacional / Exposição por Inalação / Cresóis / Poluentes Ocupacionais do Ar / Diazepam Limite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda