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[Gender differences in lipocalin 2 plasmatic levels are correlated with age and the triglyceride/high-density lipoprotein ratio in healthy individuals]. / Las diferencias de género en los niveles plasmáticos de la lipocalina 2 se correlacionan con la edad y con la proporción de triglicéridos y lipoproteínas de alta densidad en individuos sanos.
De la Chesnaye, Elsa; Manuel-Apolinar, Leticia; Oviedo-de Anda, Norma; Revilla-Monsalve, María Cristina; Islas-Andrade, Sergio.
Afiliação
  • De la Chesnaye E; Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
  • Manuel-Apolinar L; Research Unit in Endocrine Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
  • Oviedo-de Anda N; Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
  • Revilla-Monsalve MC; Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
  • Islas-Andrade S; Research Unit in Metabolic Diseases, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
Gac Med Mex ; 152(5): 612-617, 2016.
Article em Es | MEDLINE | ID: mdl-27792695
INTRODUCTION: The increment of lipocalin 2, also called neutrophil gelatinase-associated lipocalin, plasmatic levels is associated with cardiometabolic and nefrologic alterations. Nonetheless, there is much controversy about lipocalin 2 plasmatic concentrations among healthy individuals. AIM: The aim of this study was to quantify lipocalin 2 in plasma of healthy men and women and to assess a possible correlation with cardiometabolic risk factors. METHODS: Fifty-three subjects (24 men and 29 women) were included. By means of an ELISA, a higher concentration of lipocalin 2 was observed in men than in women (91 ± 9 vs. 57 ± 7 ng/ml). Such difference was statistically significant (p < 0.0001). RESULTS: Lipocalin 2 levels were significantly correlated with body mass index, homeostasis model assessment index-insulin resistance index, triglycerides, high-density lipoprotein, and age. CONCLUSION: Lipocalin 2 plasmatic concentrations present a gender-specific profile in healthy subjects and its circulating levels appear to be age-dependent and associated with several cardiometabolic risk factors, including the triglycerides/high-density lipoprotein cholesterol ratio, which has proven to be a reliable marker for cardiometabolic risk among the global population.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Fatores Sexuais / Lipocalina-2 / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: México
Buscar no Google
Adicionar na Minha BVS
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Fatores Sexuais / Lipocalina-2 / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Gac Med Mex Ano de publicação: 2016 Tipo de documento: Article País de afiliação: México País de publicação: México