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Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice.
Graus-Nunes, Francielle; Marinho, Thatiany de Souza; Barbosa-da-Silva, Sandra; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos Alberto; Souza-Mello, Vanessa.
Afiliação
  • Graus-Nunes F; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Marinho TS; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Barbosa-da-Silva S; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Aguila MB; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Mandarim-de-Lacerda CA; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Souza-Mello V; Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil. Electronic address: souzamello.uerj@gmail.com.
Mol Cell Endocrinol ; 439: 54-64, 2017 01 05.
Article em En | MEDLINE | ID: mdl-27780713
Obesity leads to adverse endocrine pancreas remodelling, reduced islet lifespan and early type 2 diabetes onset. AT1R blockade shows beneficial pleiotropic effects. This study sought to compare the effects of losartan and telmisartan on pancreatic islets remodelling and glucose homeostasis in diet-induced obese mice. High-fat diet yielded overweight, insulin resistance, islet apoptosis and hypertrophy. Suitable insulin levels and preserved endocrine pancreas structure were correlated to adequate AKT-FOXO1 pathway functioning in losartan-treated animals. Conversely, telmisartan yielded enhanced PDX1 and GLP-1 islet expression along with greater GLP-1 levels, with the consequent better islet glucose sensing and uptake. Greater islet vascularisation coupled with reduced apoptosis and macrophage infiltration seems to underlie the beneficial findings in both treatments. In conclusion, these results provide compelling evidence that two antihypertensive drugs (telmisartan and losartan) ameliorate pancreatic islet structure, glucose handling, and vascularisation in obese mice. Although only telmisartan countered overweight, both drugs yielded reduced apoptosis and islet preservation, with translational potential.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Antagonistas de Receptores de Angiotensina / Glucose / Homeostase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Antagonistas de Receptores de Angiotensina / Glucose / Homeostase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda