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The 3,4-dioxygenated 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids. Results of 20 years of research, uncovering a new family of natural products.
Simonetti, Sebastian O; Larghi, Enrique L; Kaufman, Teodoro S.
Afiliação
  • Simonetti SO; Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas - Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina. kaufman@iquir-conicet.gov.ar.
  • Larghi EL; Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas - Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina. kaufman@iquir-conicet.gov.ar.
  • Kaufman TS; Instituto de Química Rosario (IQUIR, CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas - Universidad Nacional de Rosario, Suipacha 531, (2000) Rosario, Argentina. kaufman@iquir-conicet.gov.ar.
Nat Prod Rep ; 33(12): 1425-1446, 2016 Nov 23.
Article em En | MEDLINE | ID: mdl-27714041
Covering: up to April 2016Aspergillus and Penicillium are fungal species known to produce a high diversity of secondary metabolites, many of them endowed with interesting bioactivity. The small but steadily growing family of the naturally occurring 5-hydroxy-4-aryl-quinolin-2(1H)-one alkaloids and closely related compounds, which represent the results of various research projects that spanned over 20 years and involved scientists from different continents, are covered here. Emphasis is placed on the isolation and chemical structures of the different compounds, together with their source microorganisms, environmental conditions, country or region of origin, and relevant biological activities. In addition, stereochemical aspects, as well as the proposed biosynthetic pathways for the different members, and the incipient synthetic efforts towards some of the compounds or their key intermediates, are discussed in detail.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Aspergillus / Produtos Biológicos / Alcaloides Idioma: En Revista: Nat Prod Rep Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Aspergillus / Produtos Biológicos / Alcaloides Idioma: En Revista: Nat Prod Rep Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido