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Embryo-larval exposure to atrazine reduces viability and alters oxidative stress parameters in Drosophila melanogaster.
Figueira, Fernanda Hernandes; Aguiar, Lais Mattos de; Rosa, Carlos Eduardo da.
Afiliação
  • Figueira FH; Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil.
  • Aguiar LM; Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil.
  • Rosa CE; Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Av. Itália km 8, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil. Electronic address: carlosrosa@furg.br.
Comp Biochem Physiol C Toxicol Pharmacol ; 191: 78-85, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27687474
The herbicide atrazine has been used worldwide with subsequent residual contamination of water and food, which may cause adverse effects on non-target organisms. Animal exposure to this herbicide may affect development, reproduction and energy metabolism. Here, the effects of atrazine regarding survival and redox metabolism were assessed in the fruit fly D. melanogaster exposed during embryonic and larval development. The embryos (newly fertilized eggs) were exposed to different atrazine concentrations (10µM and 100µM) in the diet until the adult fly emerged. Pupation and emergence rates, developmental time and sex ratio were determined as well as oxidative stress parameters and gene expression of the antioxidant defence system were evaluated in newly emerged male and female flies. Atrazine exposure reduced pupation and emergence rates in fruit flies without alterations to developmental time and sex ratio. Different redox imbalance patterns were observed between males and females exposed to atrazine. Atrazine caused an increase in oxidative damage, reactive oxygen species generation and antioxidant capacity and decreased thiol-containing molecules. Further, atrazine exposure altered the mRNA expression of antioxidant genes (keap1, sod, sod2, cat, irc, gss, gclm, gclc, trxt, trxr-1 and trxr-2). Reductions in fruit fly larval and pupal viability observed here are likely consequences of the oxidative stress induced by atrazine exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrazina / Estresse Oxidativo / Drosophila melanogaster / Herbicidas Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrazina / Estresse Oxidativo / Drosophila melanogaster / Herbicidas Limite: Animals Idioma: En Revista: Comp Biochem Physiol C Toxicol Pharmacol Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos