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Neurobehavioral effects of vigabatrin and its ability to induce DNA damage in brain cells after acute treatment in rats.
Sousa, Karen; Decker, Natalia; Pires, Thienne Rocha; Papke, Débora Kuck Mausolff; Coelho, Vanessa Rodrigues; Pflüger, Pricila; Pereira, Patrícia; Picada, Jaqueline Nascimento.
Afiliação
  • Sousa K; Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, Canoas, RS, 2425-900, Brazil.
  • Decker N; Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, Canoas, RS, 2425-900, Brazil.
  • Pires TR; Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, Canoas, RS, 2425-900, Brazil.
  • Papke DK; Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, Canoas, RS, 2425-900, Brazil.
  • Coelho VR; Laboratory of Neuropharmacology and Pre-Clinical Toxicology. Pharmacology Department, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Sarmento Leite Street, 500/305, Porto Alegre, RS, 90050-170, Brazil.
  • Pflüger P; Laboratory of Neuropharmacology and Pre-Clinical Toxicology. Pharmacology Department, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Sarmento Leite Street, 500/305, Porto Alegre, RS, 90050-170, Brazil.
  • Pereira P; Laboratory of Neuropharmacology and Pre-Clinical Toxicology. Pharmacology Department, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Sarmento Leite Street, 500/305, Porto Alegre, RS, 90050-170, Brazil.
  • Picada JN; Laboratory of Toxicological Genetics, Lutheran University of Brazil (ULBRA), Farroupilha Avenue, 8001, Canoas, RS, 2425-900, Brazil. jnpicada@gmail.com.
Psychopharmacology (Berl) ; 234(1): 129-136, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27678549
RATIONALE: Vigabatrin (VGB) is a drug indicated mostly for the treatment of spasms in childhood and West's syndrome patients. This drug inhibits irreversibly the enzyme GABA-transaminase (GABA-T), increasing GABA concentrations and enhancing GABAergic neurotransmission in the brain, which is known to induce behavioral changes. OBJECTIVES: The aims of this study were to evaluate the effects of VGB in the short-term memory (STM), long-term memory (LTM), motivation, locomotion, and exploratory behavior tests and to detect deleterious or protective effects on DNA in target tissues of the drug. METHODS: Male Wistar rats were treated with a single dose of VGB (100, 250, or 500 mg/kg) or saline solution before the inhibitory avoidance and open-field tasks. DNA damage was evaluated using the alkaline comet assay in peripheral blood, cerebral cortex, and hippocampus after behavioral testing. RESULTS: There was no significant difference in the inhibitory avoidance task between the treated groups and the saline group. In all tested doses, VGB reduced the number of rearings in the open-field task. Besides, VGB 500 mg/kg affected locomotion, though it was not able to induce any DNA damage. CONCLUSIONS: VGB did not affect STM and LTM, but the drug impaired the exploration and locomotion likely associated with its sedative effect. In addition, no DNA damage in cortex and hippocampus was detected after behavioral testing, when brain GABA levels are already increased.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Dano ao DNA / Encéfalo / Vigabatrina / Anticonvulsivantes Limite: Animals / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Animal / Dano ao DNA / Encéfalo / Vigabatrina / Anticonvulsivantes Limite: Animals / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha