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Pleomorphic adenoma and adenoid cystic carcinoma of salivary glands: E-cadherin immunoexpression and analysis of the CDH1 -160C/A polymorphism.
Cavalcante, Roberta Barroso; Nonaka, Cassiano Francisco Weege; Rabenhorst, Silvia Helena Barem; da Costa Miguel, Márcia Cristina; Pinto, Leão Pereira; de Souza, Lélia Batista.
Afiliação
  • Cavalcante RB; Department of Oral Pathology, University of Fortaleza, Fortaleza, CE, Brazil.
  • Nonaka CF; Department of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil.
  • Rabenhorst SH; Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
  • da Costa Miguel MC; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Pinto LP; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Souza LB; Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: leliabsouza@gmail.com.
Arch Oral Biol ; 73: 48-54, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27665273
OBJECTIVE: Despite their similar cellular origin, pleomorphic adenomas (PA) and adenoid cystic carcinomas (ACC) present distinct behaviors. This study aimed to analyze the immunoexpression of E-cadherin in PA and ACC of salivary glands, and to investigate differences in its expression in relation to E-cadherin gene (CDH1) -160C/A polymorphism. DESIGN: Twenty-four PA (15 cell-rich and 9 cell-poor tumors) and 24 ACC (10 tubular, 8 cribriform and 6 solid tumors) were selected for the analysis of pattern of distribution, and cellular localization of E-cadherin. In addition, E-cadherin expression was evaluated using the H-score scoring system. The CDH1 -160C/A polymorphism was investigated by PCR-RFLP. RESULTS: No significant differences in pattern of distribution (p=0.181) and cellular localization (p=0.192) of E-cadherin were observed between PA and ACC. Comparison of PA and ACC cases revealed a higher median H-score in the latter (p=0.036). Cell-rich PA presented a higher H-score than cell-poor tumors (p=0.013), whereas no significant differences in E-cadherin expression were observed between ACC subtypes (p=0.254). The heterozygous genotype of the CDH1 -160C/A polymorphism was detected in only one PA and one ACC. H-scores for tumors carrying the polymorphism were below the lower quartile of their respective groups. CONCLUSIONS: The results suggest that E-cadherin expression in PA and ACC is mainly related to cellular composition (epithelial cells versus myoepithelial cells) and degree of differentiation of myoepithelial cells in these tumors. The CDH1 -160C/A polymorphism does not seem to significantly influence the expression of E-cadherin in PA and ACC of salivary glands.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Caderinas / Carcinoma Adenoide Cístico / Adenoma Pleomorfo Limite: Humans Idioma: En Revista: Arch Oral Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Caderinas / Carcinoma Adenoide Cístico / Adenoma Pleomorfo Limite: Humans Idioma: En Revista: Arch Oral Biol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido