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A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection.
Biasin, Mara; Sironi, Manuela; Saulle, Irma; Pontremoli, Chiara; Garziano, Micaela; Cagliani, Rachele; Trabattoni, Daria; Lo Caputo, Sergio; Vichi, Francesca; Mazzotta, Francesco; Forni, Diego; Riva, Stefania; Aguilar-Jimenez, Wbeimar; Cedeño, Samandhy; Sanchez, Jorge; Brander, Christian; Zapata, Wildeman; Rugeles, Maria Teresa; Clerici, Mario.
Afiliação
  • Biasin M; Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157, Milan, Italy. Electronic address: mara.biasin@unimi.it.
  • Sironi M; Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.
  • Saulle I; Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157, Milan, Italy.
  • Pontremoli C; Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.
  • Garziano M; Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157, Milan, Italy.
  • Cagliani R; Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.
  • Trabattoni D; Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, 20157, Milan, Italy.
  • Lo Caputo S; S. Maria Annunziata Hospital, 50122, Florence, Italy.
  • Vichi F; S. Maria Annunziata Hospital, 50122, Florence, Italy.
  • Mazzotta F; S. Maria Annunziata Hospital, 50122, Florence, Italy.
  • Forni D; Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.
  • Riva S; Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.
  • Aguilar-Jimenez W; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
  • Cedeño S; AIDS Research Institute-IrsiCaixa-HIVACAT, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; University of Vic and Central Catalonia, Vic, Spain.
  • Sanchez J; Asociación Civil Impacta Salud y Educación, Lima, Peru.
  • Brander C; AIDS Research Institute-IrsiCaixa-HIVACAT, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; University of Vic and Central Catalonia, Vic, Spain.
  • Zapata W; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia; Grupo Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia.
  • Rugeles MT; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
  • Clerici M; Don C. Gnocchi Foundation ONLUS, IRCCS, 20148, Milan, Italy.
Microbes Infect ; 19(1): 69-74, 2017 Jan.
Article em En | MEDLINE | ID: mdl-27652980
We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta-analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4+ T lymphocytes indicated that homozygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / HIV-1 / Resistência à Doença / Receptor Celular 1 do Vírus da Hepatite A / Aminoácidos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Asia / Colombia / Europa / Peru Idioma: En Revista: Microbes Infect Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / HIV-1 / Resistência à Doença / Receptor Celular 1 do Vírus da Hepatite A / Aminoácidos Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Asia / Colombia / Europa / Peru Idioma: En Revista: Microbes Infect Assunto da revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: França