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Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study.
Mendes, Ramon Barreto; Dias, Rosane Borges; Figueiredo, Andreia Leal; Gurgel, Clarissa Araújo; Santana Filho, Manoel; Melo, Leonardo Araújo; Trierveiler, Marília; Cury, Patrícia Ramos; Leonardi, Rosalia; Dos Santos, Jean Nunes.
Afiliação
  • Mendes RB; Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
  • Dias RB; Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
  • Figueiredo AL; Department of Public Health, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
  • Gurgel CA; Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
  • Santana Filho M; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Melo LA; Laboratory of Surgical Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
  • Trierveiler M; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Cury PR; Department of Periodontics, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
  • Leonardi R; Department of Medical and Surgical Sciences, University of Catania, Catania, Italy.
  • Dos Santos JN; Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
J Oral Pathol Med ; 46(4): 297-300, 2017 Apr.
Article em En | MEDLINE | ID: mdl-27647326
BACKGROUND: Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOTs including five associated with Gorlin-Goltz syndrome) and non-aggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry. RESULTS: Glypican-3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumors including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases (P > 0.05; Fisher's exact Test). All cases of unicystic ameloblastoma (n = 4), adenomatoid odontogenic tumor (n = 5), and calcifying cystic odontogenic tumor (n = 2) were negative. CONCLUSIONS: This provided insights into the presence of glypican-3 in odontogenic tumors. This protein distinguished aggressive from non-aggressive odontogenic tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Odontogênicos / Glipicanas Limite: Humans Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Odontogênicos / Glipicanas Limite: Humans Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca