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Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices.
Tasat, Deborah R; Bruno, Marcos E; Domingo, Mariela; Gurman, Pablo; Auciello, Orlando; Paparella, María L; Evelson, Pablo; Guglielmotti, María B; Olmedo, Daniel G.
Afiliação
  • Tasat DR; School of Science and Technology, National University of San Martin, Buenos Aires, Argentina.
  • Bruno ME; Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
  • Domingo M; School of Science and Technology, National University of San Martin, Buenos Aires, Argentina.
  • Gurman P; Department of Oral Pathology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
  • Auciello O; Department of Oral Pathology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
  • Paparella ML; Research Fellow of the National Inter-university Council, Buenos Aires, Argentina.
  • Evelson P; Department of Materials Science and Engineering, University of Texas-Dallas, Richardson, Texas, United States of America.
  • Guglielmotti MB; Departments of Materials Science and Engineering and Biomedical Engineering, University of Texas-Dallas, Richardson, Texas, United States of America.
  • Olmedo DG; Department of Oral Pathology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina.
J Biomed Mater Res B Appl Biomater ; 105(8): 2408-2415, 2017 Nov.
Article em En | MEDLINE | ID: mdl-27618508
Although Ultrananocrystalline diamond (UNCD) has been proposed as a coating material for titanium biomedical implants, the biological effects and toxicity of UNCD particles that could eventually detach have not been studied to date. The biokinetics and biological effects of UNCD compared to titanium dioxide (TiO2 ) nanoparticles was evaluated in vivo using Wistar rats (n = 30) i.p. injected with TiO2 , UNCD or saline solution. After 6 months, blood, lung, liver, and kidney samples were histologically analyzed. Oxidative damage by membrane lipidperoxidation (thiobarbituric acid reactive substances-TBARS), generation of reactive oxygen species (superoxide anion- O2-), and antioxidant enzymes (superoxide dismutase-SOD, catalase-CAT) was evaluated in lung and liver. Histologic observation showed agglomerates of TiO2 or UNCD in the parenchyma of the studied organs, though there were fewer UNCD than TiO2 deposits. In addition, TiO2 caused areas compatibles with foci of necrosis in the liver and renal hyaline cylinders. Regarding UNCD, no membrane damage (TBARS) or mobilization of enzymatic antioxidants was observed either in lung or liver samples. No variations in O2- generation were observed in lung (Co: 35.1 ± 4.02 vs. UNCD: 48 ± 9.1, p > 0.05). Conversely, TiO2 exposure caused production of O2- in alveolar macrophages and consumption of catalase (p < 0.05). The studied parameters suggest that UNCD caused neither biochemical nor histological alterations, and therefore may prove useful as a surface coating for biomedical implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2408-2415, 2017.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Titânio / Teste de Materiais / Materiais Revestidos Biocompatíveis / Nanodiamantes Limite: Animals Idioma: En Revista: J Biomed Mater Res B Appl Biomater Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Titânio / Teste de Materiais / Materiais Revestidos Biocompatíveis / Nanodiamantes Limite: Animals Idioma: En Revista: J Biomed Mater Res B Appl Biomater Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos