Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro.
Rev Soc Bras Med Trop
; 49(4): 491-3, 2016.
Article
em En
| MEDLINE
| ID: mdl-27598637
INTRODUCTION: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. METHODS: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. RESULTS: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. CONCLUSIONS: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
HIV
/
Antígenos de Plaquetas Humanas
/
Hepacivirus
/
Carga Viral
Limite:
Humans
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil