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Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology.
Montalli, Victor Angelo Martins; Passador-Santos, Fabricio; Martinez, Elizabeth Ferreira; Furuse, Cristiane; Aguiar, Maria Cássia; Soares, Fernando Augusto; Soares, Andresa Borges; Brown, Amy Louise; de Araújo, Ney Soares; de Araújo, Vera Cavalcanti.
Afiliação
  • Montalli VA; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • Passador-Santos F; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • Martinez EF; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • Furuse C; Department of Oral Pathology, State University of São Paulo, Araçatuba, SP, Brazil.
  • Aguiar MC; Department of Oral Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Soares FA; Department of Anatomic Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.
  • Soares AB; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • Brown AL; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • de Araújo NS; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
  • de Araújo VC; Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
J Oral Pathol Med ; 46(3): 182-187, 2017 Mar.
Article em En | MEDLINE | ID: mdl-27591391
BACKGROUND: Polymorphous low-grade adenocarcinoma (PLGA) remains a diagnostic challenge for most pathologists due to its large spectrum of histological patterns. In this study, the expression of two new markers recently described for salivary gland tumors was studied in PLGA. METHODS: The morphology of 33 cases of PLGA was carefully evaluated using hematoxylin-and-eosin-stained sections and confirmed by immunohistochemistry for cytokeratin 7, vimentin, and S-100. Periodic acid-Schiff with diastase digestion was also used. The expression of mammaglobin and DOG-1 was carried out using the EnVision System. Mammaglobin was assessed according to the percentage of positively stained tumor cells, while DOG-1 was evaluated according to its presence and site. For MCM-2 and Ki-67, markers of proliferation, the labeling index of cell nuclei positivity was evaluated using total cell number. The ETV6-NTRK3 fusion was examined by fluorescence in situ hybridization analysis. RESULTS: The histological patterns of the tumor were classified as lobular or non-lobular. For the non-lobular pattern, tubular, cribriform, glomeruliform, trabecular, and papillary patterns were observed. Mammaglobin was present in all PLGA cases, and its expression was stronger (P = 0.01) in the lobular than in the non-lobular pattern. The expression of DOG-1 was present in the apical portion and cytoplasm of the cells. Proliferation markers were low for all cases independent of histological pattern. CONCLUSIONS: Polymorphous low-grade adenocarcinoma has been confirmed to originate from the intercalated duct and to feature high expression of mammaglobin in its lobular pattern resembling that of mammary secretory analogue carcinoma, except for the ETV6 gene rearrangement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Adenocarcinoma / Biomarcadores Tumorais / Mamoglobina A / Anoctamina-1 / Proteínas de Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Adenocarcinoma / Biomarcadores Tumorais / Mamoglobina A / Anoctamina-1 / Proteínas de Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Assunto da revista: ODONTOLOGIA / PATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca