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A family-based association study of the HTR1B gene in eating disorders.
Hernández, Sandra; Camarena, Beatriz; González, Laura; Caballero, Alejandro; Flores, Griselda; Aguilar, Alejandro.
Afiliação
  • Hernández S; Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
  • Camarena B; Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
  • González L; Clínica de Trastornos Alimentarios, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
  • Caballero A; Clínica de Trastornos Alimentarios, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
  • Flores G; Hospital y Atención Psiquiátrica Continua, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
  • Aguilar A; Departamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México.
Braz J Psychiatry ; 38(3): 239-42, 2016.
Article em En | MEDLINE | ID: mdl-27579596
OBJECTIVE: To explore the association of three polymorphisms of the serotonin receptor 1Dß gene (HTR1B) in the etiology of eating disorders and their relationship with clinical characteristics. METHODS: We analyzed the G861C, A-161T, and A1180G polymorphisms of the HTR1B gene through a family-based association test (FBAT) in 245 nuclear families. The sample was stratified into anorexia nervosa (AN) spectrum and bulimia nervosa (BN) spectrum. In addition, we performed a quantitative FBAT analysis of anxiety severity, depression severity, and Yale-Brown-Cornell Eating Disorders Scale (YBC-EDS) in the AN and BN-spectrum groups. RESULTS: FBAT analysis of the A-161T polymorphism found preferential transmission of allele A-161 in the overall sample. This association was stronger when the sample was stratified by spectrums, showing transmission disequilibrium between the A-161 allele and BN spectrum (z = 2.871, p = 0.004). Quantitative trait analysis showed an association between severity of anxiety symptoms and the C861 allele in AN-spectrum participants (z = 2.871, p = 0.004). We found no associations on analysis of depression severity or preoccupation and ritual scores in AN or BN-spectrum participants. CONCLUSIONS: Our preliminary findings suggest a role of the HTR1B gene in susceptibility to development of BN subtypes. Furthermore, this gene might have an impact on the severity of anxiety in AN-spectrum patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anorexia Nervosa / Polimorfismo de Nucleotídeo Único / Receptor 5-HT1B de Serotonina / Bulimia Nervosa / Estudos de Associação Genética Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anorexia Nervosa / Polimorfismo de Nucleotídeo Único / Receptor 5-HT1B de Serotonina / Bulimia Nervosa / Estudos de Associação Genética Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil