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Indomethacin inhibits the effects of oestrogen in the anterior pituitary gland of the rat.
Rosental, D G; Machiavelli, G A; Cherñavsky, A C; Speziale, N S; Burdman, J A.
Afiliação
  • Rosental DG; Departamento de Endocrinología, Centro de Investigaciones Médicas Albert Einstein, Buenos Aires, Argentina.
J Endocrinol ; 121(3): 513-9, 1989 Jun.
Article em En | MEDLINE | ID: mdl-2754375
Two inhibitors of prostaglandin synthesis, indomethacin and aspirin, blocked the increase of oestrogen-binding sites in the nuclear subcellular fraction, an increase which occurs after the administration of oestradiol. Consequently the biological effects of oestrogens in the anterior pituitary gland of the rat (prolactin synthesis, concentration of progesterone-binding sites and cell proliferation) are diminished. The anterior pituitary gland synthesized prostaglandin F2 alpha (PGF2 alpha), PGE2 and PGD2 from arachidonic acid. This synthesis was blocked when indomethacin was added to the culture media. Oestrogen increased the concentration of PGE2: an increase that was partially prevented by indomethacin. Prostaglandins may have an important role on the effects of oestrogen in the anterior pituitary gland of the rat.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Indometacina / Antagonistas de Estrogênios Limite: Animals Idioma: En Revista: J Endocrinol Ano de publicação: 1989 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Indometacina / Antagonistas de Estrogênios Limite: Animals Idioma: En Revista: J Endocrinol Ano de publicação: 1989 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido