Your browser doesn't support javascript.
loading
Comparative analysis of platelet 5-HT concentrations in Han and Li patients with post-traumatic stress disorder.
Li, L; Li, M X; Pan, L H; Wang, G M; Guo, M; Fu, L Q; Guo, J C; Gao, Y S; Chen, F; Xie, M X.
Afiliação
  • Li L; Department of Nursing, Nongken Hospital of Hainan Province, Haikou, China.
  • Li MX; Department of Nursing, Nongken Hospital of Hainan Province, Haikou, China.
  • Pan LH; Department of Nursing, Nongken Hospital of Hainan Province, Haikou, China.
  • Wang GM; Department of Nursing, Nongken Hospital of Hainan Province, Haikou, China.
  • Guo M; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
  • Fu LQ; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
  • Guo JC; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
  • Gao YS; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
  • Chen F; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
  • Xie MX; Department of Psychiatrist, Hainan General Hospital of Hainan Province, Haikou, China.
Genet Mol Res ; 15(3)2016 Jul 15.
Article em En | MEDLINE | ID: mdl-27525843
We investigated the role of serotonin (5-HT) in the pathogenesis of post-traumatic stress disorder (PTSD) by determining the platelet 5-HT concentrations in Li and Han patients with PTSD in Hainan Province, China. Li and Han control groups of the same sample size have no statistical differences in gender and age distribution compared to those in the PTSD groups who were also examined. The platelet 5-HT concentrations were determined by high-performance liquid chromatography. In addition, the patients and controls were evaluated by the impact of event scale-revised (IES-R). IES-R showed that the total and sub-scale scores of three factors (avoidance, intrusion, and hyperarousal) of Li patients with PTSD were significantly higher than those of Han patients with PTSD. Scores of both PTSD groups were higher than those of their respective control groups. The platelet 5-HT concentration of the Li patients with PTSD (120.56 ± 118.05 ng/10(9) platelets) was lower than that of the Han patients with PTSD (271.43 ± 181.66 ng/10(9) platelets) and that of both Li and Han control groups (338.54 ± 156.46, 350.58 ± 169.19 ng/10(9) platelets, respectively). Differences existed in symptoms of PTSD in terms of avoidance, intrusion, and hyperarousal in the Li and Han patients with PTSD. The diminished 5-HT activity in patients with PTSD may be relevant to biochemical changes in the brain and body. The differences in these factors between ethnic groups could be due to their customs, social status, and culture.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Estresse Pós-Traumáticos / Plaquetas / Serotonina Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Estresse Pós-Traumáticos / Plaquetas / Serotonina Limite: Adult / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China País de publicação: Brasil