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Low intensity ultrasound therapy induces angiogenesis and persistent inflammation in the chronic phase of the healing process of third degree burn wounds experimentally induced in diabetic and non-diabetic rats.
Fantinati, Marcelo Silva; Mendonça, Diego Eterno Oliveira; Fantinati, Adriana Márcia Monteiro; Santos, Bruno Flamarion Dos; Reis, Juliana Cristina Oliveira; Afonso, Cristina Lopes; Vinaud, Marina Clare; Lino, Ruy de Souza.
Afiliação
  • Fantinati MS; PhD, Full Professor, Superior School of Physical Education and Physical Therapy of Goias State (ESEFFEGO), Universidade Estadual de Goiás (UEG), Goias-GO, Brazil. Intellectual, scientific, conception and design of the study;manuscript writing.
  • Mendonça DE; Fellow Master degree, Postgraduation Program in Host-Parasite Relationship, Tropical Pathology and Public Health Institute, UFG, Goias-GO, Brazil. Acquisition of data.
  • Fantinati AM; Master, Assistant Professor, ESEFFEGO, UEG, Goias-GO, Brazil. Acquisition of data.
  • Santos BF; Graduate student, Physical Therapy, ESEFFEGO, UEG, Goias-GO, Brazil. Acquisition of data.
  • Reis JC; Graduate student, Physical Therapy, ESEFFEGO, UEG, Goias-GO, Brazil. Acquisition of data.
  • Afonso CL; Specialist, Assistant Professor, ESEFFEGO, UEG, Goias-GO, Brazil. Conception and design of the study.
  • Vinaud MC; PhD, Associate Professor, Tropical Pathology and Public Health Institute, Universidade Federal de Goiás (UFG), Goias-GO, Brazil. Analysis and interpretation of data, manuscript writing.
  • Lino Rde S; PhD, Associate Professor, Tropical Pathology and Public Health Institute, UFG, Goias-GO, Brazil Scientific and intellectual content of the study, analysis and interpretation of data, statistical analysis, manuscript preparation.
Acta Cir Bras ; 31(7): 463-71, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27487281
PURPOSE: To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats. METHODS: One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group. The therapy was performed with a 3MHz ultrasound application, pulsed emission at 100Hz frequency, modulated at 20% with a dosage of 0.5W/cm2 during three minutes throughout 30 days. The surgical debridement of the wound was performed once at day 2. The wounds were morphometrically, macroscopically and microscopically evaluated at 3, 7, 14, 21 and 30 days. RESULTS: The wound contraction and collagen quantification were higher in all treated groups. Macroscopically, necrosis was higher in the diabetic control group. Granulation tissue was higher in treated groups during the proliferative and remodeling phase. Microscopically, there were greater mononuclear inflammatory infiltration, angiogenesis and fibroblast quantification in treated groups during the proliferative and remodeling phases. CONCLUSIONS: therapeutic ultrasound is beneficial in the inflammatory and proliferative phases of the healing process because it controlled the necrotic tissue, increased the granulation tissue and wound contraction. However in the remodeling phase it is not beneficial because of the continued angiogenesis and a mononuclear inflammatory infiltration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Terapia por Ultrassom / Cicatrização / Queimaduras / Indutores da Angiogênese / Diabetes Mellitus Experimental Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Terapia por Ultrassom / Cicatrização / Queimaduras / Indutores da Angiogênese / Diabetes Mellitus Experimental Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil