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Diet-Induced Maternal Obesity Alters Insulin Signalling in Male Mice Offspring Rechallenged with a High-Fat Diet in Adulthood.
Fante, Thaís de; Simino, Laís Angélica; Reginato, Andressa; Payolla, Tanyara Baliani; Vitoréli, Débora Cristina Gustavo; Souza, Monique de; Torsoni, Márcio Alberto; Milanski, Marciane; Torsoni, Adriana Souza.
Afiliação
  • Fante Td; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Simino LA; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Reginato A; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Payolla TB; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Vitoréli DC; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Souza Md; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Torsoni MA; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Milanski M; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
  • Torsoni AS; Laboratory of Metabolic Disorders, School of Applied Sciences, University of Campinas-UNICAMP, Limeira, São Paulo, Brazil.
PLoS One ; 11(8): e0160184, 2016.
Article em En | MEDLINE | ID: mdl-27479001
Modern lifestyle has resulted in an increase in the prevalence of obesity and its comorbidities in pregnant women and the young population. It has been well established that the consumption of a high-fat diet (HFD) has many direct effects on glucose metabolism. However, it is important to assess whether maternal consumption of a HFD during critical periods of development can lead to metabolic changes in the offspring metabolism. This study evaluated the potential effects of metabolic programming on the impairment of insulin signalling in recently weaned offspring from obese dams. Additionally, we investigated if early exposure to an obesogenic environment could exacerbate the impairment of glucose metabolism in adult life in response to a HFD. Swiss female mice were fed with Standard Chow (SC) or a HFD during gestation and lactation and tissues from male offspring were analysed at d28 and d82. Offspring from obese dams had greater weight gain and higher adiposity and food intake than offspring from control dams. Furthermore, they showed impairment in insulin signalling in central and peripheral tissues, which was associated with the activation of inflammatory pathways. Adipose tissue was ultimately the most affected in adult offspring after HFD rechallenge; this may have contributed to the metabolic deregulation observed. Overall, our results suggest that diet-induced maternal obesity leads to increased susceptibility to obesity and impairment of insulin signalling in offspring in early and late life that cannot be reversed by SC consumption, but can be aggravated by HFD re-exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Dieta Hiperlipídica / Insulina / Obesidade Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Dieta Hiperlipídica / Insulina / Obesidade Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos