Established and Emerging Strategies in the Treatment of Chronic Kidney Disease.
Semin Nephrol
; 36(4): 331-42, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27475663
Chronic kidney disease (CKD) is a common condition that has become a significant public health concern. The mainstay therapeutic approach to CKD is based on renin-angiotensin system blockade as well as blood pressure and glycemic control. Despite these interventions, the management of CKD remains suboptimal, with a large proportion of the CKD population progressing to end-stage renal disease. Newer strategies for the treatment of CKD have emerged over the past years focusing on decreasing inflammation and delaying the development of fibrosis. Despite promising results in experimental models and small randomized studies, adequately powered randomized trials are required to evaluate the benefits and risks of these therapies in the CKD population. In this review, we discuss the evidence behind, and gaps in our knowledge of, established therapies as well as newer potential strategies for managing CKD, concentrating on interventions that currently are being evaluated in randomized studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
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Diabetes Mellitus
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Nefropatias Diabéticas
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Antagonistas de Receptores de Mineralocorticoides
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Insuficiência Renal Crônica
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Antagonistas de Receptores de Angiotensina
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Hipertensão
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Hipoglicemiantes
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Semin Nephrol
Ano de publicação:
2016
Tipo de documento:
Article
País de publicação:
Estados Unidos