Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression.

Corrales, Eyleen; Navarro, Arcadi; Cuenca, Patricia; Campos, Domingo

Corrales, Eyleen; Navarro, Arcadi; Cuenca, Patricia; Campos, Domingo.

Afiliação

Corrales E; Institute of Psychological Research (IIP), University of Costa Rica (UCR), 2060 San José, Costa Rica; Institute for Health Research (INISA), University of Costa Rica (UCR), 2060 San José, Costa Rica. Electronic address: eyleen.corrales@ucr.ac.cr.
Navarro A; Institute of Evolutionary Biology (IBE), Barcelona Biomedical Research Park (PRBB), E-08003 Barcelona, Spain.
Cuenca P; Institute for Health Research (INISA), University of Costa Rica (UCR), 2060 San José, Costa Rica.
Campos D; Institute of Psychological Research (IIP), University of Costa Rica (UCR), 2060 San José, Costa Rica.

Psychiatry Res ; 244: 71-7, 2016 Oct 30.

Article em En | MEDLINE | ID: mdl-27472173

RESUMO

Alterations in the monoaminergic neurotransmission systems are suspected to be involved in the etiology of neuropsychiatric disorders, including depression. The role of these pathways in the risk of developing depressive symptoms during childhood or adolescence is still not completely clear. This study sought to identify putative genetic factors in genes of serotonergic and dopaminergic systems modulating the level of manifestation of depressive symptoms in children and adolescents. We analyzed 170 single nucleotide polymorphisms (SNPs) in 21 candidate dopaminergic and serotonergic genes in a non-clinical sample of 410 Costa Rican participants of ages between 7 and 18 years, assessing the severity of depressive symptoms through the Child Depression Inventory (CDI). Genotypic and haplotypic associations, as well as epistatic effects, were examined. A significant interaction effect was detected between rs1039089 in conjunction with rs877138 located upstream of the dopamine D1 receptor (DRD1) and the dopamine D2 receptor (DRD2) genes respectively, although no evidence was found for any single variant or haplotype related to a differential liability. This newly described genetic interaction among putative regulatory regions of dopamine receptors could affect the level of manifestation of depressive symptoms through an imbalance of D1-D2 heteromers and modulation of cognitive processes.

Assuntos

Depressão/genética; Epistasia Genética/genética; Estudos de Associação Genética/métodos; Polimorfismo de Nucleotídeo Único/genética; Receptores de Dopamina D1/genética; Receptores de Dopamina D2/genética; Adolescente; Criança; Costa Rica/epidemiologia; Depressão/diagnóstico; Depressão/epidemiologia; Feminino; Variação Genética/genética; Genótipo; Haplótipos; Humanos; Masculino; Fatores de Risco

Palavras-chave

Depressive symptom; Dopamine; Epistasis; Genetic factors; Heteromers; Receptor; Serotonin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Dopamina D2 / Receptores de Dopamina D1 / Polimorfismo de Nucleotídeo Único / Depressão / Epistasia Genética / Estudos de Associação Genética Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America central / Costa rica Idioma: En Revista: Psychiatry Res Ano de publicação: 2016 Tipo de documento: Article País de publicação: Irlanda

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