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GPX1 Pro198Leu polymorphism and GSTM1 deletion do not affect selenium and mercury status in mildly exposed Amazonian women in an urban population.
Rocha, Ariana V; Rita Cardoso, Bárbara; Zavarize, Bruna; Almondes, Kaluce; Bordon, Isabella; Hare, Dominic J; Teixeira Favaro, Déborah Inês; Franciscato Cozzolino, Silvia Maria.
Afiliação
  • Rocha AV; Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, Brazil.
  • Rita Cardoso B; Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, Brazil; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia. Electronic address: barbara.rita@f
  • Zavarize B; Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, Brazil.
  • Almondes K; Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, Brazil.
  • Bordon I; Laboratory of Instrumental Neutron Activation Analysis (INAA), Research Reactor Centre, IPEN - Nuclear and Energy Research Institute, São Paulo, Brazil.
  • Hare DJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia; Elemental Bio-Imaging Facility, University of Technology Sydney, Broadway, New South Wales, Australia.
  • Teixeira Favaro DI; Laboratory of Instrumental Neutron Activation Analysis (INAA), Research Reactor Centre, IPEN - Nuclear and Energy Research Institute, São Paulo, Brazil.
  • Franciscato Cozzolino SM; Faculty of Pharmaceutical Sciences, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, Brazil.
Sci Total Environ ; 571: 801-8, 2016 Nov 15.
Article em En | MEDLINE | ID: mdl-27450956
Mercury is potent toxicant element, but its toxicity can be reduced by forming a complex with selenium for safe excretion. Considering the impact of mercury exposure in the Amazon region and the possible interaction between these two elements, we aimed to assess the effects of Pro198Leu polymorphism to GPX1 and GSTM1 deletion, on mercury levels in a population from Porto Velho, an urban locality in the Brazilian Amazon region. Two hundred women from the capital city of Rondônia state were recruited for this study with 149 deemed suitable to participate. We assessed dietary intake using 24-hour recall. Selenium levels in plasma and erythrocytes were measured using hydride generation quartz tube atomic absorption spectroscopy and total hair mercury using cold vapor atomic absorption spectrometry. Oxidative stress parameters (GPx activity, oxygen radical absorbency capacity [ORAC] and malondialdehyde [MDA]) were also analyzed. All participants were genotyped for Pro198Leu polymorphism and GSTM1 deletion. We observed that this population presented high prevalence of selenium deficiency, and also low levels of mercury, likely due to food habits that did not include selenium-rich food sources or significant consumption of fish (mercury biomagnifiers) regularly. Univariate statistical analysis showed that Pro198Leu and GSTM1 genotypes did not affect selenium and mercury levels in this population. Pro198Leu polymorphism and GSTM1 deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio / Poluentes Ambientais / Glutationa Peroxidase / Glutationa Transferase / Mercúrio Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Total Environ Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio / Poluentes Ambientais / Glutationa Peroxidase / Glutationa Transferase / Mercúrio Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sci Total Environ Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda