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Efficacy and safety of chloral hydrate sedation in infants for pulmonary function tests. / Eficácia e segurança do hidrato de cloral na sedação de lactentes para testes de função pulmonar.
Wandalsen, Gustavo Falbo; Lanza, Fernanda de Cordoba; Nogueira, Márcia Cristina Pires; Solé, Dirceu.
Afiliação
  • Wandalsen GF; Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil. Electronic address: gfwandalsen@uol.com.br.
  • Lanza FC; Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil; Universidade Nove de Julho, São Paulo, SP, Brasil.
  • Nogueira MC; Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  • Solé D; Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
Rev Paul Pediatr ; 34(4): 408-411, 2016 Dec.
Article em En, Pt | MEDLINE | ID: mdl-27449074
OBJECTIVE: To describe the efficacy and safety of chloral hydrate sedation in infants for pulmonary function tests. METHODS: All sedation attempts for pulmonary function tests in infants carried out between June 2007 and August 2014 were evaluated. Obstructive sleep apnea and heart disease were contraindications to the exams. Anthropometric data, exam indication, used dose, outcomes of sedation and clinical events were recorded and described. RESULTS: The sedation attempts in 277 infants (165 boys) with a median age of 51.5 weeks of life (14 to 182 weeks) were evaluated. The main indication for the tests was recurrent wheezing (56%) and the chloral hydrate dose ranged from 50 to 80mg/kg (orally). Eighteen (6.5%) infants had some type of clinical complication, with the most frequent being cough and/or airway secretion (1.8%); respiratory distress (1.4%) and vomiting (1.1%). A preterm infant had bradycardia for approximately 15 minutes, which was responsive to tactile stimulation. All observed adverse effects were transient and there was no need for resuscitation or use of injectable medications. CONCLUSIONS: The data demonstrated that chloral hydrate at the employed doses is a safe and effective medicament for sedation during short procedures in infants, such as pulmonary function tests. Because of the possibility of severe adverse events, recommendations on doses and contraindications should be strictly followed and infants should be monitored by trained staff.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Função Respiratória / Hidrato de Cloral / Sedação Consciente / Hipnóticos e Sedativos Tipo de estudo: Guideline / Observational_studies Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En / Pt Revista: Rev Paul Pediatr Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testes de Função Respiratória / Hidrato de Cloral / Sedação Consciente / Hipnóticos e Sedativos Tipo de estudo: Guideline / Observational_studies Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En / Pt Revista: Rev Paul Pediatr Ano de publicação: 2016 Tipo de documento: Article País de publicação: Brasil